Capsaicin and central control of thermoregulation

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    • Socially constructed or physiologically informed? Placing humans at the core of understanding cooling needs

      2021, Energy Research and Social Science
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      In fact, in certain hot geographies, thermogenic food such as hot peppers and spicy foods may help people coping with extreme heat because it is believed to enhance thermal transpiration and induce hypothermia. Capsaicin (8-methyl-N-vanillyl-6-nonenamide), which is responsible for the pungent gustatory sensation of hot peppers ‘when administered orally, parenterally or intracerebrally, may produce a fall in body temperature’[63]. Importantly, metabolism changes with movement with the particular role of activities, habits and routines that make up daily life.

    • Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse

      2019, Physiology and Behavior
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      On the other hand, a single subcutaneous administration of CAP at the dose of 1–10 mg/kg decreases colon temperature and increases skin surface temperature in immobilized rats for 2 h [14,16–19]. A single subcutaneous administration of low-dose CAP also causes a long-lasting hyperthermia >10 h after decrease of colon temperature in immobilized rats [16,17,20]. A single subcutaneous administration of low-dose CAP results in profound hypothermia that reaches its nadir by 30 min and recovers within 2 h in freely moving wild-type (WT) mice using a telemetry system, while no such decrease is observed in TRPV1 knockout (KO) mice [21].

    • The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish

      2018, Brain, Behavior, and Immunity
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      Although it is not clear how prostaglandin is responsible for the induction of behavioural fever in ectotherms, our results, together with the findings from Dhaka et al. (2006), suggest that changes in thermoregulatory behaviour could be mediated by the activation of transient receptor potential channels (TRP) (Gavva et al., 2007; Hori, 1984; Jancsó-Gábor et al., 1970; Swanson et al., 2005). Several studies have suggested a key role of TRP channels in temperature sensing and thermoregulation in endotherms (Gavva et al., 2007; Hori, 1984; Jancsó-Gábor et al., 1970; Swanson et al., 2005). In mammals for example, TRPM2 (transient receptor potential channel M2) ion channels function as ionotropic warm receptors in hypothalamic neurons to limit the fever response (Song et al., 2016).

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