Dopaminergic neurons in the rat ventral tegmental area. II. Evidence for autoregulation

doi:10.1016/0165-0173(81)90003-5

Brain Research Reviews

Volume 3, Issue 2, October 1981, Pages 141-151

https://doi.org/10.1016/0165-0173(81)90003-5 Get rights and content

Abstract

Previous studies have shown that the firing activity of A10 DA neurons are depressed following antidromic stimulation of the NAc. This study present data showing that the N Ac-induced effect might be mediated by a direct DA dendrodendritic and/ or axon collateral inhibitory system. The evidence may be summarized as follows:

1.
(1) the response of A10 DA neurons to stimulation of the Nac depended upon antidromic invasion of DA fibers; either destruction of DA projections or acutely blocked DA transmission by 6-OHDA prevented the depressant response of the great majority of A10 cells to NAc-stimulation,
2.
(2) DA antagonists either blocked or markedly reduced NAc-induced depressant effect on identified A10 DA neurons, and
3.
(3) iontophoresis of DA consistently inhibited firing of identified A10 DA neurons. However, destruction of neuronal perikarya in the NAc by ibotenic acid also caused a reduction of NAc-induced effect. The latter finding suggests that in addition to the DA autoregulatory system in the VTA, afferent inputs from the NAc may also contribute to the NAc-induced depressant effect on A10 DA cells.

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Dopaminergic neurons in the rat ventral tegmental area. II. Evidence for autoregulation

Abstract

Brain Research

Brain Research

Neurosci. Lett.

Brain research

Brain Research

Brain Research

Brain Research

Neurosci. Lett.

Brain Research

Brain Research

Life Sci.

Europ. J. Pharmacol.

Neuroscience

Brain Research

Brain Research

Life Sci.

Neuroscience

Brain Research

Electroenceph. clin. Neurophysiol.

Neuropharmacology

Brain Research

Brain Res. Rev.

Brain Res. Rev.

Europ. J. Pharmacol.

Brain Research

Brain Research

Dopamine autoreceptors: pharmacological characterization by microiontophoretic single cell recording studies

Naunyn-Schmiedeberg's Arch. Pharmacol.

Ascending monoamine neurons to the telecephalon and dieneephalon

Acta physiol. scand.

5,7-Dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain

Z. Zellforsch.

3,4-Dihydroxyphenylacetic acid (DOPAC) and the rat mesolimbic dopaminergic pathway: drug effects and evidence for somatodendritic mechanisms

Brit. J. Pharmacol.

Neurochemical studies of the mesolimbic dopaminergic pathway: somatodendritic mechanisms and GABAergic neurons in the rat ventral tegmentum

J. Neurochem.

5,7-Dihydroxytryptamine: improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine

J. Neurochem.