Research paperInjection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons
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2019, Brain ResearchCitation Excerpt :The Cm of neurons in the ventral hippocampus was 140.1 ± 16.22 pF vs. 150.8 ± 18.25 pF in control and HIV Tg rats, respectively (n = 13–15). The dynamic clamp method allows the dynamic control of the injected current with the purpose of better reproducing natural synaptic inputs in neurons (Chance and Abbott, 2009; Economo et al., 2010; Robinson and Kawai, 1993; Sharp et al., 1993). The current that is injected into the cell membrane using the dynamic clamp is calculated using computation methods and then readjusted with a high frequency (>10 kHz) to take into account the continuously changing membrane potential of the neuron (Chance and Abbott, 2009; Economo et al., 2010).
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