Research paperInjection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons
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2019, Brain ResearchCitation Excerpt :The Cm of neurons in the ventral hippocampus was 140.1 ± 16.22 pF vs. 150.8 ± 18.25 pF in control and HIV Tg rats, respectively (n = 13–15). The dynamic clamp method allows the dynamic control of the injected current with the purpose of better reproducing natural synaptic inputs in neurons (Chance and Abbott, 2009; Economo et al., 2010; Robinson and Kawai, 1993; Sharp et al., 1993). The current that is injected into the cell membrane using the dynamic clamp is calculated using computation methods and then readjusted with a high frequency (>10 kHz) to take into account the continuously changing membrane potential of the neuron (Chance and Abbott, 2009; Economo et al., 2010).
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2015, Current BiologyCitation Excerpt :We recorded the sequence of EPSCs evoked by the input action potential train (Figures 2A and 2B) and examined (in current clamp mode) the resulting action potential train that these EPSCs generated (Figure 2C). After converting the EPSCs to conductance changes, we used dynamic clamp [20] to inject into the cell soma the recorded conductance scaled up or down by different factors (see Experimental Procedures), so that we could examine the voltage response that would be produced by a larger or smaller synaptic conductance. The dynamic clamp technique uses a computer interface to calculate how much current needs to be injected into the cell to mimic the synaptic conductance while the membrane potential is changing.
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