Elsevier

Psychiatry Research

Volume 26, Issue 1, October 1988, Pages 19-28
Psychiatry Research

High-dose naloxone in tardive dyskinesia

https://doi.org/10.1016/0165-1781(88)90083-2Get rights and content

Abstract

Tardive dyskinesia (TD) is thought to result from nigrostriatal dopaminergic supersensitivity secondary to prolonged neuroleptic exposure. Preclinical studies have demonstrated that the opiate antagonist naloxone can acutely reverse a haloperidol-induced hyperdopaminergic state. In a trial of high-dose naloxone, 20 patients with TD received i.v. naloxone (20 mg, 40 mg, and placebo) under double-blind conditions. At baseline and at regular postdrug intervals, patients were evaluated using a battery of motor, clinical, and neuropsychological measures to study effects on neurological, behavioral, and cognitive functions. There was a significant improvement in involuntary movements at 30 min postnaloxone, together with improvement in clinical ratings at that time point, as well as some cognitive changes. The implications of these findings for the putative functional relationship between dopaminergic and enkephalinergic systems in the nigrostriatal area are discussed.

References (53)

  • T.F. Seeger et al.

    Selective inhibition of mesolimbic behavior supersensitivity by naloxone

    European Journal of Pharmacology

    (1980)
  • R. Simantov et al.

    The regional distribution of a morphine-like factor enkephalin in monkey brain

    Brain Research

    (1976)
  • L. Terenius et al.

    Increased CSF levels of endorphins in chronic psychosis

    Neuroscience Letters

    (1976)
  • B.H.C. Westerink et al.

    Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain

    European Journal of Pharmacology

    (1975)
  • American Psychiatric Association

    DSM-III: Diagnostic and Statistical Manual of Mental Disorders

    (1980)
  • A.L. Benton

    The Revised Visual Retention Test

    (1974)
  • P. Berger et al.

    The effects of naloxone in chronic schizophrenia

    American Journal of Psychiatry

    (1981)
  • N. Bjorndal et al.

    Enkephalin, morphine and naloxone in tardive dyskinesia

    Psychopharmacology

    (1980)
  • H. Buschke et al.

    Evaluating storage, retention and retrieval in disordered memory and learning

    Neurology

    (1974)
  • K.R. Carlson et al.

    Behavioral supersensitivity to apomorphine following chronic narcotic treatment in the guinea pig

    Psychopharmacology

    (1978)
  • G.E. Crane

    Tardive dyskinesia in patients treated with major neuroleptics: A review of the literature

    American Journal Psychiatry

    (1968)
  • H.M. Emrich

    A possible role of endorphinergic systems in schizophrenia

  • H.M. Emrich et al.

    Indication of an antipsychotic action of the opiate antagonist naloxone

    Pharmakopsychiatrie, Neuropsychopharmacologie

    (1977)
  • A. Herz

    Plasma levels of β-endorphin under chronic neuroleptic treatment in neuroleptic drugs

  • M. Gallagher et al.

    Opiate antagonists improve spatial memory

    Science

    (1983)
  • C.J. Golden

    Stroop Color and Word Test

    (1978)
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