Caffeine taste test for panic disorder: Adenosine receptor supersensitivity
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Cited by (34)
What is the link between personality and food behavior?
2022, Current Research in Food ScienceCitation Excerpt :Macht (1999) has suggested that those individuals who are more sensitive to bitter tastes are also likely to jump/react more strongly to sudden loud noises. Those suffering from panic disorder, by contrast, have been shown to exhibit a reduced sensitivity to quinine (DeMet, Stein, Tran, Chicz-DeMet et al., 1989). Meanwhile, levels of anxiety are positively correlated with an individual's bitter and salt taste thresholds (Heath et al., 2006).
Both anxiety and joint laxity determine the olfactory features in panic disorder
2018, Psychiatry ResearchCitation Excerpt :Although the data are limited, several studies have provided evidence of an increased sensitivity to internal and external sensory cues in this type of patients. PD patients have lower thresholds and greater reactivity to somatic sensations (Domschke et al., 2010), visual peripheral stimulation (Caldirola et al., 2011), light (Bossini et al., 2009, 2013), sounds (Jüris et al., 2013), taste stimuli (DeMet et al., 1989), and also to meteorological phenomena (Bulbena et al., 2005). In the area of olfaction, our group recently evaluated the olfactory function in PD and found that PD patients appeared to be highly sensitive, reactive and aware of odors compared to controls (Burón et al., 2015).
Olfactory functioning in panic disorder
2015, Journal of Affective DisordersCitation Excerpt :To date, no study has addressed the olfactory sensitivity (i.e. detection threshold) and the reactivity to odors in PD. Interestingly, several reports on other sensorial modalities have found a hypersensitivity and a high reactivity in patients suffering from PD to somatic sensations (Domschke et al., 2010; Ogawa et al., 2010), visual peripheral stimulation (Caldirola et al., 2011), light (Bossini et al., 2009, 2013), sounds (Jüris et al., 2013), taste (DeMet et al., 1989), and also to meteorological phenomena (Bulbena et al., 2005). These findings are consistent with the heightened arousal and hypervigilance often seen in these types of patients (Brown and McNiff, 2009).
Cognitive enhancers for anxiety disorders
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Similar observations have been made in social phobics fearing public performance situations, although with mixed results for generalized social anxiety cases (Nardi et al., 2008; Aouizerate et al., 2004). This, with other studies directly measuring adenosine receptor activity with caffeine administration, have strongly suggested a link between fear of physical symptoms and a particular sensitivity to caffeine-induced neural activity at adenosine receptor sites (DeMet et al, 1989; Nardi et al., 2008). In order to better parse out how caffeine may impact the fear and alarm circuitry, several studies have used caffeine challenge tasks with individuals meeting criteria for panic disorder.
Modulation of methylphenidate effects on wheel running and acoustic startle by acute food deprivation in commercially and selectively bred rats
2011, Pharmacology Biochemistry and BehaviorModeling risk factors for nicotine and other drug abuse in the preclinical laboratory
2009, Drug and Alcohol Dependence
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Edward DeMet, Ph.D., is Associate Professor in Residence