Caffeine taste test for panic disorder: Adenosine receptor supersensitivity

doi:10.1016/0165-1781(89)90014-0

Psychiatry Research

Volume 30, Issue 3, December 1989, Pages 231-242

https://doi.org/10.1016/0165-1781(89)90014-0 Get rights and content

Abstract

The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold guinine concentrations. The test is used to compare gustatory adenosinergic responses to caffaine challenges in normal controls and patients with panic disorder or posttraumatic stress disorder (PTSD). Panic disorder patients had an exaggerated response to the caffeine challenge that was not found in controls or PTSD patients, although the latter had higher anxiety scores on psychometric tests. The results are related to a model in which A₁-adenosine receptors up-regulate in an attempt to modulate hyperactive excitatory neuronal systems.

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^∗: Edward DeMet, Ph.D., is Associate Professor in Residence

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Caffeine taste test for panic disorder: Adenosine receptor supersensitivity

Abstract

Neuroscience Letters

Journal of Biological Chemistry

Neuropharmacology

Psychiatry Research

European Journal of Pharmacology

Pharmacology, Biochemistry and Behavior

Pharmacology, Biochemistry and Behavior

Journal of Psychiatric Research

Neuroscience

Journal of Biological Chemistry

Lactate infusion in post-traumatic stress disorder

DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders

Caffeine consumption and anxiety: Preliminary results of a survey comparing patients with anxiety disorders and normal controls

Psychopharmacology Bulletin

Increased sensitivity to caffaine in patients with panic disorders

Archives of General Psychiatry

The SCL-90: An outpatient psychiatric rating scale

Psychopharmacology Bulletin

Caffeine as a drug of abuse

The light microscopic in vitro autoradiographic localization of adenosine (A1) receptors

Neurosciences Abstracts

Autoradiographic localization of adenosine receptors in rat brain using 3H-cyclohexyladenosine

Journal of Neuroscience

The light microscopic in vitro autoradiographic localization of adenosine (A₁) receptors

Autoradiographic localization of adenosine receptors in rat brain using ³H-cyclohexyladenosine