Research reportRadial glia of developing human fetal spinal cord: Golgi, immunohistochemical and electron microscopic study
References (22)
- et al.
Immunofluorescence staining of astrocytes in vitro using antiserum to glial fibrillary acidic protein
Brain Research
(1975) - et al.
The demonstration of glial fibrillary acidic protein in the cerebrum of the human fetus by indirect immunofluorescence
Brain Research
(1976) - et al.
Localization of glial fibrillary acidic protein in astrocytes by immunofluorescence
Brain Research
(1972) - et al.
Differentiation of astrocytes in the cerebellar cortex and the pyramidal tracts of the newborn rat
- et al.
Interactions of neurons and astrocytes during growth and development of human fetal brain in vitro
Exp. molec. Pathol.
(1976) - et al.
Radial glia in the human fetal cerebrum: a combined Golgi, immunofluorescent and electron microscopic study
Brain Research
(1978) - et al.
Evolution of Bergmann glia in developing human fetal cerebellum: a Golgi, electron microscopic and immunofluorescent study
Brain Research
(1980) - et al.
An acidic protein isolated from fibrous astrocytes
Brain Research
(1971) Mechanism of neuronal migration in human fetal cerebrum in vitro
Yonsei Med. J.
(1979)- Choi, B. H., Hematogenous cells in developing human embryos and fetuses, J. comp. Neurol., in...
Localization of antigen in tissue cells. II. Improvements in a method for the detection of antigen by means of fluorescent antibody
J. exp. Med.
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Common cues wire the spinal cord: Axon guidance molecules in spinal neuron migration
2019, Seminars in Cell and Developmental BiologyCitation Excerpt :Spinal neurons are born in the neuroepithelium in the ventricular zone (VZ) [1,2], with the ventral neurons generated slightly earlier than the dorsal ones [3]. At the onset of neurogenesis, undifferentiated neuroprogenitors initially undergo radial migration away from the ventricle, often along extended radial glial processes [4–6] (Fig. 1). Neuroprogenitors then exit the cell cycle and move out of the VZ [1,2].
The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair
2018, Progress in NeurobiologyCitation Excerpt :During this phase, NE cells also express a variety of intermediate filament proteins such as vimentin and in some non-rodent species, glial fibrillary acidic protein (GFAP; Mori et al., 2005). The accumulation of cytoplasmic glycogen granules that can be detecting using electron microscopy, is a defining characteristic of the transformation of NE cells to a glial phenotype (Choi, 1981). The above molecular changes mark the transition of NE to RG cells.
Radial glial cells: Key organisers in cns development
2014, International Journal of Biochemistry and Cell BiologyCitation Excerpt :This cell type, with its long radial process, was originally discovered spanning the foetal spinal cord by Camillo Golgi in 1885 (Rakic, 2003). Ramon Cajal originally suggested a glial identity for these cells by demonstrating their morphological similarities with astrocytes, but their glial phenotype was ultimately confirmed 60 years later when immunohistochemistry and electron microscopy showed that radial glial cells contain glycogen granules and GFAP, which are intracellular characteristics found only in glia (Choi, 1981; Levitt and Rakic, 1980). Today, radial glial cells are recognised as morphologically, biochemically and functionally distinct from other neural cell types.
Fetal Development of the Central Nervous System
2012, The Human Nervous System, Third EditionRoles of reactive oxygen and nitrogen species in pain
2011, Free Radical Biology and MedicineCitation Excerpt :In support, administration of an NR1 antisense oligonucleotide reduces c-fos expression [191]. Extracellular glutamate concentration has to be kept low enough to terminate glutamate receptor activation and to protect neurons from glutamate excitotoxicity [205–207]. Glutamate is not metabolized by extracellular enzymes, but rather has to be removed from the synaptic cleft by cellular uptake.
Cellular expression of the K <sup>+</sup>-Cl <sup>-</sup> cotransporter KCC3 in the central nervous system of mouse
2011, Brain ResearchCitation Excerpt :These results lead us to conclude that astrocytes in the adult mouse CNS do not seem to express KCC3a. Similarly to astrocytes, radial glial cells of primate cortex contain glycogen granules (Choi, 1981) and express GFAP (Levitt and Rakic, 1980). Rodent radial glial cells hardly express any detectable levels of GFAP mRNA (Sancho-Tello et al., 1995) but express the astrocyte-specific glutamate transporter (GLAST) (Shibata et al., 1997), 3CB2 antigen (Prada et al., 1995) and brain lipid-binding protein (BLBP) (Feng et al., 1994; Feng and Heintz, 1995).