Research reportTestosterone fails to save androgen-sensitive rat motoneurons following early target removal
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Cited by (19)
Androgenic mechanisms of sexual differentiation of the nervous system and behavior
2017, Frontiers in NeuroendocrinologyCitation Excerpt :Given that the effects of conditional ARKO in myocytes is similar between developmental and adult myocyte ARKO (Rana et al., 2016), we infer that the reduction in LA size reflects an activational effect, rather than an organizational effect. Nonetheless, we remain confident that the site of action of androgen in the organization of a masculine SNB system is in the vicinity of the target muscles, as extirpation or local flutamide treatment of target muscles prevents masculinization of SNB motoneurons in rats (Kurz et al., 1992; Fishman and Breedlove, 1992). Selective genetic manipulations have also been used to study activational androgenic influence on the SNB system.
Androgen regulation of axon growth and neurite extension in motoneurons
2008, Hormones and BehaviorCell death and sexual differentiation of the nervous system
2006, NeuroscienceCell death of spinal interneurones
2000, Progress in NeurobiologyCitation Excerpt :Circulating hormones may also modulate cell survival, although in some instances, such as the androgen-dependent perineal motoneurones in the lower lumbar spinal cord, their action appears to be mediated indirectly through maintenance of the target muscles rather than directly on the motoneurones (Kurz et al., 1992).
Hormonally induced neuronal plasticity in the adult motoneurons
1997, Brain Research Bulletin