Fc receptor for IgG (FcR) on rat microglia

doi:10.1016/0165-5728(94)90176-7

Journal of Neuroimmunology

Volume 49, Issues 1–2, January 1994, Pages 19-24

https://doi.org/10.1016/0165-5728(94)90176-7 Get rights and content

Abstract

Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.

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Fc receptor for IgG (FcR) on rat microglia

Abstract

Immunol. Today

Anal. Biochem.

Anal. Biochem.

Neurosci. Lett.

J. Neuroimmunol.

Neuroscience

Brain Res.

J. Neuroimmunol.

Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells

Eur. J. Immunol.

Ameboid microglia as effectors of inflammation in the central nervous system

J. Neurosci. Res.

Characterization of ameboid microglia isolated from developing mammalian brain

J. Neurosci.

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

J. Neurosci. Res.

Microglia cells in primary cultures exposed to triethylead

ATLA