Research paperIndirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine
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2017, Psychiatry ResearchCitation Excerpt :Shared activated immune-inflammatory and oxidative and nitrosative stress (IO&NS) pathways underpin the pathogenesis of depression and MS (Gonsette, 2008; Ortiz et al., 2013; Morris and Maes, 2013; Maes, 1993; Maes et al., 2011a). Both diseases are characterized by increased pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, increased positive acute phase proteins (APPs), such as C-reactive protein (CRP), lowered levels of negative APPs, such as albumin (Kallaur et al., 2015; Maes, 2011), increased lipid peroxidation (Maes et al., 2011c; Morris and Maes, 2013), and autoimmune responses, including natural autoimmune responses to oxidatively and nitrosatively modified neo-epitopes (Morris and Maes, 2013; Moylan et al., 2014; Boullerne et al., 1995). Individuals with MS and depression show more peripheral inflammation than MS patients without depression as indicated by increased IL-6 and lowered albumin and IL-4 (Kallaur et al., 2015).
Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis
2016, Journal of Clinical NeuroscienceMechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles
2013, Journal of Biological ChemistryIgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis
2013, Journal of NeuroimmunologyCitation Excerpt :Anti-SNOcys IgM was identified in the CSF of MS patients. We have previously reported this IgM antibody in serum (Boullerne et al., 1995, 2002) and found it in serum also in the present study. Strikingly, in the control group affected by other milder neurological diseases, CSF anti-SNOcys IgM was detected only at background level (Fig. 1a).