The role of descending inhibition in morphine-induced analgesia

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Abstract

It is generally accepted that morphine produces analgesia through both a direct action in the brain and the spinal cord, and an indirect action by increasing descending inhibitory control of spinal nociceptive input. In examining the evidence for this position, Claire Advokat questions the conclusion that morphine enhances descending, supraspinally mediated inhibition. She presents recent results that support the conclusion that morphine acts in the brain to decrease descending inhibition of spinal nociceptive input.

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