Trends in Pharmacological Sciences
Current awarenessThe transmitter-gated channels: a range of receptor types and structures
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Homology modeling and atomic level binding study of GABA<inf>A</inf> receptor with novel enaminone amides
2010, European Journal of Medicinal ChemistryCitation Excerpt :They both contain many β-sheet structures in the extramembrane segments. In addition, O’Mara et al. [26] have reported a GABAA receptor by using the crystal structure of AChBP from the L. stagnalis (PDB code 1i9b, 2.7 Å) as the template in 2005. When we make the study, a recently resolved structure (PDB code 2ZJU) is used, which owns higher resolution than 1I9B.
Cross-talk and Co-trafficking between ρ1/GABA Receptors and ATP-gated Channels
2004, Journal of Biological ChemistryProlonged exposure to γ-aminobutyric acid up-regulates stably expressed recombinant α1β2γ2s GABA<inf>A</inf> receptors
2003, European Journal of PharmacologyDescending control of pain
2002, Progress in NeurobiologyCitation Excerpt :GABAA receptors, like 5-HT3 and nicotinic receptors, comprise pentameric ion channels which are assembled from-at least 18-different subunits. However, they may be distinguished from the former by their permeability to anions (chloride) underlying an inhibitory influence upon cellular excitability (Barnard, 1996, 2000). They possess several modulatory (facilitatory) sites, notably to volatile and intravenous anesthetics such as isoflurane and propofol, respectively (Sieghart, 1995; Krasowski et al., 1998; Vahle-Hinz et al., 2001).