Trends in Neurosciences
ViewpointThe changing scene of neurotrophic factors
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Functionalization strategies of electrospun nanofibrous scaffolds for nerve tissue engineering
2021, Smart Materials in MedicinePutative roles of soluble trophic factors in facial nerve regeneration, target reinnervation, and recovery of vibrissal whisking
2018, Experimental NeurologyCitation Excerpt :In theory, the uptake of trophic factors from cells in the distal nerve stumps could substitute for the target-derived amounts of trophic factors and, keep the regenerating axons trophically satisfied until the axons regain their target-derived source (Toma et al., 1992; Unsicker et al., 1992). With the exception of CNTF, which is produced by the myelinating Schwann cells of the peripheral nerves (Henderson et al., 1994; Sendtner et al., 1994), all other factors are at least in part, target-derived, i.e. they are produced by the target tissue, taken up at synaptic terminals and reach the neuronal somata via retrograde axonal transport (Taniuchi et al., 1988; Thoenen, 1991). Accordingly, it has been shown that the intact facial nucleus of rats does not contain immunocytochemically detectable amounts of BDNF, CNTF, GDNF or NGF (Baumgartner and Shine, 1997; Stöckli et al., 1991).
BDNF and Hippocampal Synaptic Plasticity
2017, Vitamins and Hormones