Trends in Neurosciences
ReviewMolecular messengers of olfaction
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Electrical properties of cells from human olfactory epithelium
2019, Auris Nasus LarynxCitation Excerpt :OCs are neurons with a dendrite facing the interior space of the nasal cavity lined with cilia that play a role in the transduction of volatile chemical stimuli. Binding of these molecules to receptors on the surface of cilia activates intracellular cascades (for a review, see [2–4]) resulting from the opening of cyclic AMP-gated cation channels and Ca2+-gated Cl− channels [5–9]. This causes a slow and graded receptor potential [10–12] that is encoded as spike trains—i.e., voltage-dependent inward and outward currents that transmit olfactory information to the brain.
Suppression and recovery of voltage-gated currents after cocaine treatments of olfactory receptor cells
2013, Auris Nasus LarynxCitation Excerpt :These cells are neurons with a dendrite facing the interior space of the nasal cavity and characterized by the possession of cilia playing a role in the transduction of odorous stimulation. Odorant binding to receptor proteins at the ciliary surface of the receptor cell activates enzymatic cascades [5,6] causing the opening of two types of ionic channels; cAMP-gated cationic channel and Ca2+-gated Cl− channel [7–9]. They cause a slow and graded voltage change, which is called receptor potentials [10].
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