Trends in Neurosciences
Volume 16, Issue 10, October 1993, Pages 389-394
Journal home page for Trends in Neurosciences

Techniques
The dynamic clamp: artificial conductances in biological neurons

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Abstract

The dynamic clamp is a novel method that uses computer simulation to introduce conductances into biological neurons. This method can be used to study the role of various conductances in shaping the activity of single neurons, or neurons within networks. The dynamic clamp can also be used to form circuits from previously unconnected neurons. This approach makes computer simulation an interactive experimental tool, and will be useful in many applications where the role of synaptic strengths and intrinsic properties in neuronal and network dynamics is of interest.

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