A neuropharmacological study of the periventricular neural substrate involved in flight
References (68)
Induction of ‘rage’ following microinjection of glutamate into midbrain but not hypothalamus of cats
Neurosci. Lett.
(1982)- et al.
Identification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids
Behav. Brain Res.
(1985) The organization of afferent projections to the mid brain periaqueductal gray of the rat
Neuroscience
(1982)- et al.
Gaba mediation of the anti-aversive action of minor tranquilizers
Pharmacol. Biochem. Behav.
(1982) - et al.
Chlordiazepoxide and morphine reduce pressor response to brain stimulation in awake rats
Pharmacol. Biochem. Behav.
(1985) - et al.
Escape behaviour produced by blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus
Pharmacol. Biochem. Behav.
(1986) - et al.
Neuroeffector mechanisms of the defence reaction in the rat
Physiol. Behav.
(1983) - et al.
Evidence for a GABAergic inhibitory nigrotectal pathway in the rat
Neurosci. Lett.
(1981) - et al.
Picrotoxin microinjections into the brain: a model of abrupt withdrawal ‘jumping’ behaviour in rats not exposed to any opiate?
Eur. J. Pharmacol.
(1983) - et al.
The striato-nigro-collicular pathway and explosive running behaviour: functional interaction between neostriatal dopamine and collicular GABA
Eur. J. Pharmacol.
(1984)
Elicitation of intraspecific defensive behavior in the rat by microinjections of picrotoxin, a γ-aminobutyric antagonist, into the midbrain periaqueductal gray matter
Brain Res.
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation
Pharmacol. Biochem. Behav.
Chemical activation of the mesencephalic locomotor region
Brain Res.
Behavioural effects of GABA agonists and antagonists infused in the mesencephalic reticular formation-deep layers of superior colliculus
Brain Res.
Morphine and ACTH1–24: correlative behavioral excitations following micro-injections in the rat periaqueductal gray
Brain Res.
Morphine applied to the mesencephalic central gray suppresses brain stimulation induced escape
Pharmacol. Biochem. Behav.
Role of opiates and benzodiazepines in the control of centrally induced aversive effects
Behav. Brain Res.
Morphine injected into the periaqueductal gray attenuates brain-stimulation-induced aversive effects: an intensity discrimination study
Brain Res.
Discrimination between aversive brain stimulations: effect of stimulation parameter
Behav. Neural. Biol.
Afferents to the periaqueductal gray in the rat
A Horseradish peroxidase study
Neuroscience
Escape from stimulation of the trapezoid body in rats bred for escape from noise
Physiol. Behav.
Influence of midbrain stimulation on the excitability of neurons in the medial hypothalamus of the rat
Brain Res.
Forelimb and hindlimb stepping by the anesthetized rat elicited by electrical stimulation of the pons and medulla
Physiol. Behav.
Central gray and medial hypothalamic stimulation: correlation between escape behavior and unit activity
Brain Res.
Effects of hypothalamic lesions on central gray stimulation induced escape behavior and on withdrawal reactions in the rat
Physiol. Behav.
Etude des systèmes de renforcement négatif et de renforcement positif au niveau de la substance grise centrale chez le rat
Physiol. Behav.
Effets aversifs et appétitifs induits par stimulation mésencéphalique et hypothalamique
Brain Res.
Effects of central gray and raphe nuclei lesions on hypothalamically induced escape
Physiol. Behav.
Escape induced by combined stimulation in medial hypothalamus and central gray
Physiol. Behav.
Escape and approach induced by brain stimulation: a parametric analysis
Behav. Brain Res.
Behavioral effects of microinjections of SR 95103, a new GABAA antagonist, into the medial hypothalamus or the mesencephalic central gray
Eur. J. Pharmacol.
Analgesia and hyperreactivity produced by intracranial micro-injections into the PAG of the rat
Behav. Biol.
Role of the ventromedial nucleus of the thalamus in motor behavior. I. Effects of focal injections of drugs
Neuroscience
Short intrinsic circuit in the periaqueductal gray matter of the cat
Neurosci. Lett.
Cited by (63)
Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze
2014, Behavioural Brain ResearchCitation Excerpt :In fact, the electrical stimulation of the DMH induces escape behavior and autonomic arousal that resemble the ones presented by animals when facing natural threats [18–20]. Administration of glutamate agonists [13,21] and of GABA antagonists into the structure [22,23] also evokes a similar defense pattern. CRF positive neurons have been shown to be present in large numbers in the DMH [24].
Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze
2014, Brain Research BulletinChemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour
2013, European Journal of PharmacologyCitation Excerpt :Through the study of encephalic areas and connections involved in the neural basis of innate fear-induced behaviours, several pathways between encephalic aversion system (Graeff, 1990) structures have been found, such the neuroanatomical links between the dorsal columns of the periaqueductal grey matter (dPAG), the medial hypothalamus, the amygdaloid complex, the septal area (Siegel and Pott, 1988), and the reticular formation of the deep mesencephalon, pons and medulla oblonga (Coimbra et al., 2006). These neural substrates have been demonstrated to be physiologically relevant for the elaboration of unconditioned and conditioned fear-induced behaviours and pain modulation in both laboratory animals (Fernandez de Molina and Hunsperger, 1959; Lyon, 1964; Pellegrino, 1968; Halpern, 1968; Fuchs and Siegel, 1984; Fuchs et al., 1985; Schmitt et al., 1986; Coimbra et al., 2006) and humans (Tracey et al., 2002; Mobbs et al., 2007; Wilent et al., 2010). Thus, in addition to other structures such as the deep layers of the superior colliculus (Leão Borges et al., 1988; Coimbra and Brandão, 1993; Coimbra et al., 1996, 2006) and the central nucleus of the inferior colliculus (Brandão et al., 1988, 1993, 2001; Cardoso et al., 1994; Coimbra et al., 2000), the dPAG can be considered an important structure of the encephalic aversion system that is involved in the coordination and generation of instinctive fear-induced behaviour (Graeff, 1981; Fanselow, 1991; Carrive, 1993).