Network analysis of brain cognitive function using metabolic and blood flow data

doi:10.1016/0166-4328(94)00139-7

Behavioural Brain Research

Volume 66, Issues 1–2, 23 January 1995, Pages 187-193

https://doi.org/10.1016/0166-4328(94)00139-7 Get rights and content

Abstract

Functional neuroimaging has become a powerful tool for investigating the neurobiological foundations of cognition. An overview is presented of the two major strategies by which such data are currently analyzed. One strategy compares the pattern of activity between two (or more) tasks, looking for those brain areas that show significant changes. The second investigates the functional relationships between regional activities in an attempt to determine the systems-level neural networks mediating the tasks. Object and spatial visual processing tasks are used to illustrate each of these strategies.

References (34)

J.V. Haxby et al.
Dissociation of object and spatial visual processing pathways in human extrastriate cortex
J.V. Haxby et al.
Mapping human functional neuroanatomy with brain work imaging
Neuropsychologia
(1991)
H.L. Lagreze et al.
Functional cortical interaction patterns in visual perception and visuospatial problem solving
J. Neurol. Sci.
(1993)
A.R. McIntosh et al.
Structural modeling of functional neural pathways mapped with 2-deoxyglucose: effect of acoustic startle habituation on the auditory system
Brain Res.
(1991)
G.v. Bonin et al.
The Neocortex of Macaca Mulatta
(1947)
A.R. Damasio
The brain binds entities and events by multiregional activation from convergence zones
Neural Comput.
(1989)
A.R. Damasio et al.
Face agnosia and the neural substrates of memory
Annu. Rev. Neurosci.
(1990)
R. Desimone et al.
Neural mechanisms of visual processing in monkeys
D.J. Felleman et al.
Distributed hierarchical processing in primate cerebral cortex
Cereb. Cortex
(1991)
P.T. Fox et al.
Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images
J. Cereb. Blood Flow Metabol.
(1988)

K.J. Friston et al.

Comparing functional (PET) images: the assessment of significant change

J. Cereb. Blood Flow Metab.

(1991)

K.J. Friston et al.

Plastic transformation of PET images

J. Comput. Assist. Tomogr.

(1991)

K.J. Friston et al.

Functional connectivity: the principal-component analysis of large (PET) data sets

J. Cereb. Blood Flow Metab.

(1993)

C.L. Grady et al.

Dissociation of object and spatial vision in human extrastriate cortex: age-related changes in activation of regional cerebral blood flow measured with [¹⁵O]water and positron emission tomography

J. Cogn. Neurosci.

(1992)

J.V. Haxby et al.

Dissociation of object and spatial visual processing pathways in human extrastriate cortex

L. Hayduk

Structural Equation Modeling with LISREL

(1987)

B. Horwitz

Functional neural systems analyzed by use of interregional correlations of glucose metabolism

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Network analysis of brain cognitive function using metabolic and blood flow data

Abstract

Neuropsychologia

J. Neurol. Sci.

Brain Res.

The Neocortex of Macaca Mulatta

The brain binds entities and events by multiregional activation from convergence zones

Neural Comput.

Face agnosia and the neural substrates of memory

Annu. Rev. Neurosci.

Neural mechanisms of visual processing in monkeys

Distributed hierarchical processing in primate cerebral cortex

Cereb. Cortex

Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images

J. Cereb. Blood Flow Metabol.

Comparing functional (PET) images: the assessment of significant change

J. Cereb. Blood Flow Metab.

Plastic transformation of PET images

J. Comput. Assist. Tomogr.

Functional connectivity: the principal-component analysis of large (PET) data sets

J. Cereb. Blood Flow Metab.

Dissociation of object and spatial vision in human extrastriate cortex: age-related changes in activation of regional cerebral blood flow measured with [15O]water and positron emission tomography

J. Cogn. Neurosci.

Dissociation of object and spatial visual processing pathways in human extrastriate cortex

Structural Equation Modeling with LISREL

Functional neural systems analyzed by use of interregional correlations of glucose metabolism

Dissociation of object and spatial vision in human extrastriate cortex: age-related changes in activation of regional cerebral blood flow measured with [¹⁵O]water and positron emission tomography