Elsevier

Neuroscience Research

Volume 17, Issue 4, September 1993, Pages 265-290
Neuroscience Research

Review article
Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system

https://doi.org/10.1016/0168-0102(93)90111-3Get rights and content

Abstract

The neural cell adhesion molecule (NCAM) is a cell surface glycoprotein which is thought to mediate cell adhesion and recognition. During developmental stages, NCAM is highly polysialylated (NCAM-H) by a unique α-2,8-linked polysialic acid chain (PSA), and this PSA portion of NCAM-H has been found to be closely associated with various developmental processes of the nervous system. Further, recent immunohistochemical investigations have revealed that even in the adult nervous system, a persistent PSA expression has been found confined to several regions: the olfactory bulb, the piriform cortex, the hippocampal dentate gyrus, the hypothalamus, some nuclei of the medulla and the dorsal horn of the spinal cord, which are related directly or indirectly to sensory systems. Moreover, in the dentate gyrus and olfactory bulb the expression is connected with adult neurogenesis that may add new neuronal circuits to the adult neural tissue. Therefore, the possible role of NCAM-H in the central nervous system may be associated not only with neural development, but also with adult functions, such as the processing system of sensory information and neuronal plasticity.

References (206)

  • A.L. Calof et al.

    Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro

    Neuron

    (1989)
  • G.J. Cole et al.

    Identification of a heparin-binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides

    Neuron

    (1989)
  • G. Dickson et al.

    Human muscle neural cell adhesion molecule (NCAM): Identification of a muscle-specific sequence in the extracellular domain

    Cell

    (1987)
  • J. Dodd et al.

    Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons

    Neuron

    (1988)
  • P. Doherty et al.

    Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid

    Neuron

    (1990)
  • P. Doherty et al.

    Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels

    Cell

    (1991)
  • R. Dubner et al.

    Activity-dependent neuronal plasticity following tissue injury and inflammation

    Trends Neurosci.

    (1992)
  • D. Figarella-Branger et al.

    Expression of various isoforms of neural cell adhesion molecules and their highly polysialylated counterparts in diseased human muscles

    J. Neurol. Sci.

    (1990)
  • J. Finne

    Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain

    J. Biol. Chem.

    (1982)
  • J. Finne et al.

    Occurrence of α2–8 linked polysialosyl units in a neural cell adhesion molecule

    Biochem. Biophys, Res. Commun.

    (1983)
  • J. Finne

    Polysialic acid — a glycoprotein carbohydrate involved in neural adhesion and bacterial meningitis

    Trends Pharmacol. Sci.

    (1985)
  • S.E. Fraser et al.

    Alterations in the Xenopus retinotectal projection by antibodies to Xenopus N-CAM

    Dev. Biol.

    (1988)
  • S. Fushiki et al.

    Immunocytological localization of cell adhesion molecules L1 and N-CAM and the shared carbohydrate epitope L2 during development of the mouse neocortex

    Dev. Brain. Res.

    (1986)
  • D. Goldowitz et al.

    NCAM gene expression during the development of cerebellum and dentate gyrus in the mouse

    Dev. Brain Res.

    (1990)
  • C. Goridis et al.

    NCAM: structural diversity, function and regulation of expression

    Semin. Cell Biol.

    (1992)
  • J. Häyrinen et al.

    Interaction of meningococcal group B monoclonal antibody and its Fab fragment with α2–8-linked sialic acid polymers: requirement of a long oligosaccharide segment for binding

    Mol. Immunol.

    (1989)
  • S. Hoffman et al.

    Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes

    J. Biol. Chem.

    (1982)
  • M. Husmann et al.

    Up-regulation of embryonic NCAM in an EC cell line by retinoic acid

    Dev. Biol.

    (1989)
  • S. Inoue et al.

    Isolation of a novel glycoprotein from the eggs of rainbow trout: occurrence of disialosyl groups on all carbohydrate chains

    Biochem. Biophys. Res. Commun.

    (1978)
  • W.M. James et al.

    Multiple oligosaccharide chains in the voltage-sensitive Na channel from electrophorus electricus: evidence for α-2,8-linked polysialic acid

    Biochem. Biophs. Res. Comm.

    (1987)
  • E.G. Jones et al.

    Growth and maturation of the rat corticospinal tract

    Prog. Brain Res.

    (1982)
  • A. Acheson et al.

    NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions

    J. Cell Biol.

    (1991)
  • A.A. Alcantara et al.

    5B4-CAM expression parallels neurite outgrowth and synaptogenesis in the developing rat brain

    J. Comp. Neurol.

    (1992)
  • G. Alcaraz et al.

    Biosynthesis and processing of polysialylated NCAM by AtT-20 cells

    Eur. J. Cell Biol.

    (1991)
  • J. Altman et al.

    Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

    J. Comp. Neurol.

    (1965)
  • J. Altman

    Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

    J. Comp. Neurol.

    (1969)
  • J. Altman et al.

    Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods

    J. Comp. Neurol.

    (1990)
  • A. Alvarez-Buylla et al.

    Birth of projection neurons in adult avian brain may be related to perceptual or motor learning

    Science

    (1990)
  • J. Aoki et al.

    Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M

    J. Cell Biol.

    (1991)
  • C.H. Bailey et al.

    Serotonin-mediated endocytosis of apNCAM: an early step of learning-related synaptic growth in Aplysia

    Science

    (1992)
  • D. Barthels et al.

    High degree of NCAM diversity generated by alternative RNA splicing in brain and muscle

    Eur. J. Neurosci.

    (1992)
  • U. Bartsch et al.

    Highly sialylated N-CAM is expressed in adult mouse optic nerve and retina

    J. Neurocytol.

    (1990)
  • S.A. Bayer et al.

    Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life

    Science

    (1982)
  • L. Beasley et al.

    The nerve growth factor-inducible large external (NILE) glycoprotein and neural cell adhesion molecule (N-CAM) have distinct patterns of expression in the developing rat central nervous system

    J. Neurosci.

    (1987)
  • S. Bhat et al.

    Developmental expression of neural cell adhesion molecules of oligodendrocytes in vivo and in culture

    J. Neurochem.

    (1988)
  • J.L. Bixby et al.

    Neurite outgrowth on muscle cell surfaces involves extracellular matrix receptors as well as Ca2+-dependent and -independent cell adhesion molecules

  • E. Bock

    Cell-cell adhesion molecules

    Biochem. Soc. Trans.

    (1991)
  • S. Boisseau et al.

    Analysis of high PSA NCAM-expression during mammalian spinal cord and peripheral nervous system development

    Development

    (1991)
  • K.C. Breen et al.

    Developmental control of N-CAM sialylation state by Golgi sialyltransferase isoforms

    Development

    (1988)
  • K.C. Breen et al.

    Synaptosomal sialyltransferase glycosylates surface proteins that are inaccessible to the action of membrane-bound sialidase

    J. Neurochem.

    (1991)
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