Trends in Genetics
Volume 5, 1989, Pages 70-76
Journal home page for Trends in Genetics

Review
The new mouse genetics: Altering the genome by gene targeting

https://doi.org/10.1016/0168-9525(89)90029-2Get rights and content

Abstract

Gene targeting (homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA sequences) in pluripotent, mouse embryo-derived stem (ES) cells promises to provide the means to generate mice of any desired genotype. This review describes some of the background and current advances of gene targeting in mouse ES cells.

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