Trends in Genetics
Volume 9, Issue 12, December 1993, Pages 413-421
Journal home page for Trends in Genetics

Site-specific recombinases: tools for genome engineering

https://doi.org/10.1016/0168-9525(93)90104-PGet rights and content

Abstract

Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.

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