Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: Distribution and release by capsaicin
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The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas
2020, European Journal of PharmacologyTarget engagement and histopathology of neuraxial resiniferatoxin in dog
2018, Veterinary Anaesthesia and AnalgesiaCitation Excerpt :Capsaicin and a variety of structural analogues activate small peptidergic sensory afferents in vitro (Theriault et al. 1979; Akagi et al. 1980; Bucsics & Lembeck 1981; Gamse et al. 1981; Franco-Cereceda et al. 1987; Iadarola & Mannes 2011) and in vivo (Yaksh et al. 1980; Jhamandas et al. 1984; Go & Yaksh 1987; Aimone & Yaksh 1989; Iadarola & Mannes 2011).
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2018, NeuroscienceAssociation of down-regulation of calcitonin gene-related peptide and substance P with increase of myocardial vulnerability in diabetic neuropathic rats
2017, PeptidesCitation Excerpt :The impairments of intrinsic cardio-protective mechanisms may be underlying the pathological association between diabetes mellitus and cardiovascular impairments, in which adenosine, bradykinin, TNF-α, norepinephrine, opioids and other peptides [9–12] may play important roles. Calcitonin gene-related peptide (CGRP) and substance P (SP), the main constituent neuropeptides of sensory nerves [13,14], were found in cardiovascular system [15,16] and up-regulated in myocardium and sensory afferent neurons innervating the heart, during acute myocardial infarction [17,18]. Moreover, accumulating evidence indicates that CGRP and SP play important roles in mediation of cardioprotection [16–20].
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2017, Physiology and BehaviorPreservation of CGRP in myocardium attenuates development of cardiac dysfunction in diabetic rats
2016, International Journal of CardiologyCitation Excerpt :In addition to damage of myocytes, diabetes may impair cardiac performance, via disturbing the endogenous mechanism responsible for regulation and support of the cardiac function, though the underlying mechanism is still not fully understood. Calcitonin gene-related peptide (CGRP), one of the main constituent neuropeptides of sensory nerves [6], is mainly synthesized in the dorsal root ganglia (DRG) that contain the cell bodies of sensory nerves terminating peripherally on cardiovascular system [7,8] and may play important roles in mediation of cardioprotection [9–13] and regulation of cardiac function [12,14–16]. Transient receptor potential vanilloid type 1 (TRPV1), as an up-stream regulator of CGRP, is widely distributed in sensory nerve terminals, dorsal root ganglia, spinal cord [17] and in the epicardium of the heart [18].