ArticleIdentification of immunoreactive substance P in human and other mammalian endothelial cells
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Cited by (92)
The two-faced effects of nerves and neuropeptides in corneal diseases
2022, Progress in Retinal and Eye ResearchCitation Excerpt :It is encoded by the TAC1 gene, which is located on the human chromosome 7. SP is mainly released by sensory terminals, although immune (Suvas, 2017), epithelial (Watanabe et al., 2002), endothelial (Linnik and Moskowitz, 1989), and bone marrow stem cells (Li et al., 2000) can also produce it. SP exerts its biological activities by binding to tachykinin receptors (NK1R, NK2R, and NK3R) expressed in both neuronal and non-neuronal cells (Khawaja and Rogers, 1996).
Association between serum substance P levels and mortality in patients with severe sepsis
2015, Journal of Critical CareCitation Excerpt :The TAC1 gene encodes substance P (SP), a member of the tachykinin family largely considered a peptide of neuronal origin [3]. However, SP and other tachykinins are also widely distributed in nonneuronal tissues [4–7] where they mediate multiple homeostatic functions, including nociception and neurogenic inflammation [3,8]. The effects of SP are mainly mediated by the NK1receptor (NK1R), a G-protein–coupled receptor that is widely expressed in many tissues and cells [7,9].
Morphology and neurochemistry of rabbit iris innervation
2015, Experimental Eye ResearchCitation Excerpt :The presence of SP-positive cell-like structures in the both sides of the iris is a new finding. In addition to SP be recognized as a neuropeptide in sensory neurons, SP gene expression has been reported in non-neural cells, such as human fibroblasts, keratinocytes, endothelial cells, lymphocytes and platelets (Bae et al., 2002; Jones et al., 2008; Lai et al., 1998; Linnik and Moscowitz, 1989). Our previous study showed that rabbit corneal epithelial cells express SP after experimental surgery (Cortina et al., 2012).
Immunolocalization of NK-1 Receptor and Substance P in Human Normal Placenta
2010, PlacentaCitation Excerpt :Traditionally it has been classified as a neurotransmitter exerting its effects on the periphery only by being released from nerve endings. However, SP has been demonstrated in murine and human non-neuronal cell types, including endothelial cell [2,3] macrophages and monocytes [4], eosinophils [5], lymphocytes [6], and Leydig cells [7]. This suggests that it could not only act as a neurotransmitter but also as a functional regulator in an autocrine or paracrine manner.
Differentiation of neuronal from non-neuronal Substance P
2009, Regulatory PeptidesIn vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia
2008, Leukemia ResearchCitation Excerpt :As compared to mature lymphocytes, lymphoblasts carry around 3–4-fold higher amounts of receptors for SP [12]. Apart from lymphocytes, receptors for SP also can be noted on monocytes [13], endothelial cells [14], fibroblasts [15] and hematopoietic stem cells [16]. Substance P augments proliferative activity of human and mouse lymphocytes T [17,18], human smooth muscle cells [19], mouse fibroblasts [20], fibroblasts of human skin [15], smooth muscle fibers of arterial walls [21], human synovial cells [22] and human cells forming colonies of granulocytes and monocytes or of erythrocytes [23].