Elsevier

Peptides

Volume 13, Issue 3, May–June 1992, Pages 603-607
Peptides

Article
Sex differences in the effects of neuropeptide FF and IgG from neuropeptide FF on morphine- and stress-induced analgesia

https://doi.org/10.1016/0196-9781(92)90096-LGet rights and content

Abstract

There is evidence suggesting that the endogenous mammalian octapeptide FLFQPQRFamide (F8Fa or neuropeptide FF, NPFF) has modulatory effects on opioid-mediated analgesia in rodents. There is also substantial evidence for sex differences in opioid analgesia, whereby male rats and mice display greater levels of opioid-mediated analgesia than females. In the present study, determinations were made of the effects of NPFF and IgG from antiserum against NPFF on morphine- and restraint stress-induced opioid analgesia in male and female deer mice. Intracerebroventricular (ICV) administrations of NPFF (0.10–10 μg) reduced in a dose-dependent manner morphine- and stress-induced analgesia in both male and female mice, with NPFF having markedly greater antagonistic effects in the male than female mice. Additionally, ICV administrations of NPFF-IgG increased the levels of morphine- and stress-induced analgesia and significantly reduced basal nociceptive sensitivity in male mice, whereas, in female mice, NPFF-IgG had no significant effects on either opioid-mediated analgesia or nociceptive sensitivity. These results indicate that there are sex differences in the modulatory effects of NPFF on opioid-mediated analgesia.

References (36)

Cited by (36)

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    I.c.v. injection of an NPFFR2 selective agonist reversed morphine-induced analgesia (Roussin et al., 2005). Neutralization of endogenous NPFF was found to potentiate morphine analgesia (Kavaliers and Innes, 1992; Kavaliers and Yang, 1989). However, i.t. injection with NPFF or its analog produced analgesia or potentiated the opioid analgesic effect (Gouarderes et al., 1996; Kontinen and Kalso, 1995).

  • Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice

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    These observations indicate that NPFF antagonizes the antinociceptive activities induced by endogenous opioid peptides, which is consistent with previous reports [20,21]. Early studies using restraint to induced analgesia suggested that i.c.v. administrations of NPFF dose-dependently reduce SIA in mice [21]. In addition, intra-ventral tegmental area (VTA) injection of NPFF also prevented the footshock SIA in the formalin test [20].

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