ArticleNeuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats
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2019, Brain, Behavior, and ImmunityCitation Excerpt :For example, ip IL-1ß administration increases NPY levels in the PVH, but not in the ARH, which can reflect inhibition of NPY release (McCarthy et al., 1995). Moreover, intracerebroventricularly infused NPY can counter the reduction of food intake after IL-1β administration (Sonti et al., 1996). Collectively, these findings indicate that IL-1β acts on NPY-containing neurons to inhibit its release and thus favor hypophagia.
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