Biochemical and behavioural consequences of interactions between dopaminergic and noradrenergic systems in rat prefrontal cortex

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  • Cited by (13)

    • Effects of 6-hydroxydopamine lesioning of the medial prefrontal cortex on social interactions in adolescent and adult rats

      2010, Brain Research
      Citation Excerpt :

      It has been suggested that decreased DA transmission in the mPFC following 6-OHDA lesioning may remove tonic dopaminergic inhibition over cortico-fugal projection neurons, resulting in enhanced DA transmission in subcortical areas (Deutch et al., 1990; Pycock et al., 1980). Given that NE may inhibit the firing activity and the release of DA neurons by acting on α-adrenoreceptors located in the PFC (Hertel et al., 1999; Tassin et al., 1992; Tassin, 1998), one might speculate that significant destruction of noradrenergic terminals in the PFC may increase DA release in the preserved DA terminals, thus offsetting the corticofugal disinhibitory effect of DA depletion induced by 6-OHDA. This may subsequently lead to less pronounced increase or no change in DA transmission in subcortical areas, which may explain our findings (no significant changes in DA, DOPAC, and NE concentrations in the NAS of adolescent and adult lesioned rats compared to sham rats).

    • Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain

      2008, Brain Research
      Citation Excerpt :

      Compared to the mesocorticolimbic DA system, the role of NE in the mPFC in behavioral and neurochemical responses to psychostimulants have been studied to a lesser extent. DA and NE interact postsynaptically as well as presynaptically in the PFC (Tassin et al., 1992; Pan et al., 2004). The modulatory effect of prefrontal cortical NE transmission on accumbal DA has been reported to be a necessary condition for motivational salience attribution to reward-related stimuli (Ventura et al., 2007).

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