Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices
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Cited by (135)
Astrocyte-neuron circuits in epilepsy
2023, Neurobiology of DiseaseSeasonal changes in adenosine kinase in tanycytes of the Arctic ground squirrel (Urocitellus parryii)
2021, Journal of Chemical NeuroanatomyCitation Excerpt :Adenosine is metabolized by both enzymatic deamination to form inosine, and by ADK phosphorylation to form AMP. However, under normal physiological conditions, astrocytic ADK (AdK; EC 2.7.1.20) is the primary regulator of adenosine metabolism (Lloyd and Fredholm, 1995; Latini and Pedata, 2001). Therefore, altered ADK expression is significant because it reflects changes in the extracellular adenosine levels (Boison et al., 2010; Etherington et al., 2009).
Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder
2021, Pharmacological ResearchDevelopment of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization
2019, Analytical BiochemistryCitation Excerpt :The lack of a tissue blank precludes matrix matching of the calibration standards to samples and is an additonal challenge. Previous publications discuss the quantification of adenosine in various matrices: plasma, cells from culture (and media), tissue perfusate, tissue sections, cerebrospinal fluid, urine; but the majority of these methods use a liquid chromatography system coupled with a UV or fluorescence detection [7,10–17], rather than LC-MS/MS [18–21]. Additionally, a select number of publications use a derivatization technique to improve selectivity and sensitivity joined with LC-UV or LC-fluorescence to improve the properties of adenosine in plasma, urine, and/or tissue perfusate [22–27].
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels
2017, Molecular Aspects of MedicineAdenosinergic signaling in epilepsy
2016, NeuropharmacologyCitation Excerpt :In addition, adenosine has receptor independent effects that regulate biochemical enzyme reactions and that affect epigenetic functions (Williams-Karnesky et al., 2013). Whereas different sources of adenosine from neurons and astrocytes affect synaptic versus homeostatic adenosine signaling (Cunha, 2001, 2008), overall levels of adenosine are largely under the control of metabolic clearance through the astrocyte-based enzyme adenosine kinase (ADK) (Boison, 2013; Fedele et al., 2004; Lloyd and Fredholm, 1995; Pak et al., 1994). Maladaptive processes that determine adenosine availability and signaling have been associated with the development of epilepsy and – consequently – therapeutic approaches aimed at restoring normal adenosinergic function hold promise for the therapy of epilepsy (Boison, 2008, 2012a).
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Present address: Department of Pharmacology, The University of Sydney, NSW 2006, Australia.