Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
References (31)
- et al.
Age-associated structural alteration in senescent mouse brain DNA
Biochem. Biophys. Acta
(1977) - et al.
Neuron numbers and dendritic extent in normal and Alzheimer's disease
Neurobiol. Aging
(1987) - et al.
Alzheimer's disease fibroblasts have normal repair of N-methyl-N′-nitro-N-nitrosoquanidine-induced DNA damage determined by the alkaline elution technique
Biochem. Biophys. Res. Commun.
(1987) - et al.
Deficient repair of DNA lesions in Alzheimer's disease
Biochem. Biophys. Res. Commun.
(1985) - et al.
Differences in pyrimidine dimer removal between rat skin cells in vitro and in vivo
J. Invest. Dermatol.
(1988) - et al.
Age-dependent accumulation of DNA alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells
Mech. Ageing Dev.
(1988) - et al.
Radiosensitivity in Alzheimer's disease and Parkinson disease
Lancet
(1983) - et al.
Alzheimer disease fibroblasts are hypersensitive to lethal effects of DNA-damaging agents
Mutat. Res.
(1986) - et al.
Immunochemical detection of DNA in alkaline sucrose gradient fractions
J. Immunol. Methods
(1986) - et al.
DNA damage and repair in Alzheimer's disease
Electrophoretic separation of large DNA molecules by periodic inversion of the electric field
Science
(1986)
Selective messenger RNA reduction in Alzheimer's disease
Mol. Brain Res.
(1988)
Chromatin structure in dementia
Ann. Neurol.
(1984)
Susceptibility of mouse liver DNA to digestion by S1 nuclease: absence of age-related change
Age
(1979)
The patients dying after long terminal phase have acidotic brains; Implications for biochemical measurements on autopsy material
J. Neural Transm.
(1985)
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2022, Current Opinion in NeurobiologyCitation Excerpt :PARP activity is stimulated by DNA damage and plays physiological roles in DNA damage repair [58]. Parthanatos may contribute to AD pathogenesis as increased DNA damage [59,60] and diminished DNA repair activity [61,62] have been observed in tissue from AD patients. Moreover, increased activity of PARP-1 has also been observed in the brains of AD patients [63] and AD mouse models [64].
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