Elsevier

Neurobiology of Aging

Volume 12, Issue 4, July–August 1991, Pages 330-333
Neurobiology of Aging

Commentary
Plasticity in Alzheimer's disease: Too much or not enough?

https://doi.org/10.1016/0197-4580(91)90011-8Get rights and content

Abstract

The goal of optimizing restorative sprouting in Alzheimer's disease is based on the premise that sprouting is beneficial and is deficient in AD. The beneficial aspects of neuronal plasticity have been questioned, however, and other studies suggest that some aspects of sprouting may be exaggerated in AD and contribute to the formation of plaques, tangles, and other neuropathological hallmarks of this disorder. Manipulation of the sprouting response may represent a promising treatment strategy in AD, but whether the goal is to augment or impede sprouting may depend upon the extent of the damage and the severity of the disease state.

References (53)

  • J.W. Geddes et al.

    Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

    Neurosci. Lett.

    (1990)
  • K.M. Hamre et al.

    Alz-50 immunoreactivity in the neonatal rat: changes in development and codistribution with MAP-2 immunoreactivity

    Neurosci. Lett.

    (1989)
  • M. Hasegawa et al.

    Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

    Neuron

    (1990)
  • Y. Ihara

    Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

    Brain Res.

    (1988)
  • R. Katzman

    Alzheimer's disease is a degenerative disorder

    Neurobiol. Aging

    (1989)
  • J. Loesche et al.

    Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: recovery of alternation performance following unilateral entorhinal cortex lesions

    Brain Res. Bull.

    (1977)
  • E. Masliah et al.

    Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

    Neurosci. Lett.

    (1989)
  • M.M. Paula-Barbosa et al.

    Dendritic degeneration and regrowth in the cerebral cortex of patients with Alzheimer's disease

    J. Neurol. Sci.

    (1980)
  • A. Probst et al.

    Neuritic plaques in senile dementia of Alzheimer type: A Gölgi analysis in the hippocampal region

    Brain Res.

    (1983)
  • J.J. Ramirez et al.

    Recovery from perseverative behavior after entorhinal cortex lesions in rats

    Brain Res.

    (1988)
  • J.J. Ramirez et al.

    Sparing and recovery of spatial alternation performance after entorhinal cortex lesions in rats

    Behav. Brain Res.

    (1984)
  • T.M. Reeves et al.

    Changes in the firing properties of neurons in the dentate gyrus with denervation and reinnervation: Implications for behavioral recovery

    Exp. Neurol.

    (1988)
  • A. Represa et al.

    Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

    Brain Res.

    (1988)
  • S.W. Scheff et al.

    Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal

    Brain Res.

    (1980)
  • S.W. Scheff et al.

    Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting

    Behav. Biol.

    (1977)
  • S.W. Scheff et al.

    Quantitative assessment of cortical synaptic density in Alzheimer's disease

    Neurobiol. Aging

    (1990)
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