Progress in Neuro-Psychopharmacology and Biological Psychiatry
A scaling approach to find order parameters quantifying the effects of dopaminergic agents on unconditioned motor activity in rats
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iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression
2023, Pharmacology Biochemistry and BehaviorBlockade of serotonin 5-HT <inf>2A</inf> receptors potentiates dopamine D <inf>2</inf> activation-induced disruption of pup retrieval on an elevated plus maze, but has no effect on D <inf>2</inf> blockade-induced one
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :It is possible that the ways they disrupt maternal behavior are quite different. It should be noted that in other behaviors, quinpirole and haloperidol often exert an opposite effect, such as in motor activity (Paulus and Geyer, 1991), attention performance (Agnoli et al., 2013), and associative learning task (Loskutova et al., 2010). Serotonin 5-HT2A receptors are expressed throughout various cortical and subcortical areas that are involved in maternal behavior, including the VTA, NAc, dorsal striatum, and mPFC (Howell and Cunningham, 2015).
Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species
2017, NeuropharmacologyCitation Excerpt :This measure is calculated by plotting successive x-y coordinates of the path traveled against varying lengths of measuring resolutions. Distance traveled is plotted against the number of movement counts using a double-logarithmic plot, with the slope of this line of fit being used to calculate spatial d (Geyer et al., 1986; Paulus and Geyer, 1991, 1993). Values at either end of this range may indicate perseverative behavior (Perry et al., 2009; Young et al., 2010).
Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor
2013, Journal of Affective DisordersBehavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice
2013, Behavioural Brain ResearchCitation Excerpt :Spatial d, measured between values of 1 and 2, indicates the extent to which a subject travels in a straight line (close to 1) or adopts a more convoluted, meandering path, such as very localized, circumscribed movements (close to 2). This measure is calculated by plotting the successive x–y coordinates of the path traveled against varying lengths of measuring resolutions (e.g., measuring the distance traveled with a small versus large ruler) [37]. Values at either end of this range may indicate repetitive, perseverative behavior; for example, acute treatment with amphetamine induces an abnormal sequential pattern characterized by repeated running around the perimeter of the chamber, resulting in lower d values [36].
Four factors underlying mouse behavior in an open field
2012, Behavioural Brain ResearchCitation Excerpt :Thus, it was possible to measure various features of behavioral exploration in rats, including holepoking, rearing, locomotor activity, and locomotor patterns [5,9]. To assess the spatiotemporal patterns of locomotion in the BPM, Geyer and co-workers developed specific measures, such as spatial d, the spatial and temporal coefficients of variation, and entropy [6,10,11]. These measurements quantify the linearity, predictability, and the organization of exploratory behavior.