Progress in Neuro-Psychopharmacology and Biological Psychiatry
Alcohol and anxiety: Ethopharmacological approaches
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Cited by (38)
Mixed Effects of Low-dose Ethanol on Cortical and Hippocampal Theta Oscillations
2020, NeuroscienceCitation Excerpt :Alcohol is one of the most widely used drugs. Frequently, humans use ethanol as self-medication for symptoms of anxiety (Buckner et al., 2008; Robinson et al., 2009); and there are related effects with its consumption by rodents (Blanchard et al., 1993). However, for clinical use, ethanol’s deleterious effects and abuse potential far outweigh its efficacy as an anxiolytic; and its effects on defensive behaviour are more complex than benzodiazepines such as diazepam (Blanchard et al., 1993).
Nuance and behavioral cogency: How the Visible Burrow System inspired the Stress-Alternatives Model and conceptualization of the continuum of anxiety
2015, Physiology and BehaviorCitation Excerpt :The interactions are potently stressful, and nuances in behavior is what makes them uncontrollable and unpredictable [98]. Bob Blanchard created an opportunity for researchers to study how aggression and social interaction lead to the production of anxious behavior in a naturalistic model [16,18,22–37]. The colony dynamics of the VBS revealed the neural and physiological underpinnings of the stress response, and cemented many concepts which are now considered foundational in our understanding of the behavior of social species [17,19,47,48,64–66,100–110].
Animated bird silhouette above the tank: Acute alcohol diminishes fear responses in zebrafish
2012, Behavioural Brain ResearchCitation Excerpt :In the current study, however, the fear stimulus did not affect the amount of freezing performed. Notably, freezing as a fear reaction has been found context dependent [5]. For example, freezing may manifest more robustly if hiding places are provided.
Effects of alcohol on brain responses to social signals of threat in humans
2011, NeuroImageCitation Excerpt :However, not much is known about the neural mechanisms that mediate the relationship between alcohol and anxiety/negative affect. Animal studies have also shown that alcohol reduces negative affect and dampens anxiety behaviors (Blanchard et al., 1993; Spanagel et al., 1995) and have suggested that alcohol exerts this effect within the brain's limbic fear system (e.g., GABA pathway, amygdala; Allan et al., 1987; McBride, 2002; Moller et al., 1997; Sommer et al., 2001). However, the acute effect of alcohol on fear-related brain function in humans is poorly understood.
Environmental novelty and illumination modify ethanol-induced open-field behavioral effects in mice
2010, Pharmacology Biochemistry and Behavior