Platelet-derived growth factor is a mitogen for glial but not for neuronal rat brain cells in vitro
References (30)
- et al.
Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation
Cell
(1984) - et al.
Chemotaxis of rat brain astrocytes to platelet-derived growth factor
Brain Res.
(1985) Cultured retinal glial cells are insensitive to platelet-derived growth factor
Exp. Eye Res.
(1982)- et al.
The differentiation of oligodendrocytes in a serum-free hormone-supplemented medium
Dev. Brain Res.
(1984) An improved fluorometric assay for DNA
Anal. Biochem.
(1971)- et al.
Cultures from rat brain hemispheres enriched in oligodendrocyte-like cells
Brain Res.
(1979) - et al.
Oligodendroglia content of glial cell primary cultures, from newborn rat brain hemispheres, depends on the initial plating density
Neurosci. Lett.
(1980) - et al.
Fibrillary astrocytes proliferate in response to brain injury
A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine
Dev. Biol.
(1979) - et al.
Plasminogen activator is a mitogen for astrocytes in developing cerebellum
Dev. Brain Res.
(1985) - et al.
The brain fibroblast growth factor (FGF) is localized in neurons
Neurosci. Lett.
(1986)
Purification of two astroglial growth factors from bovine brain
FEBS Lett.
Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle
Biochim. Biophys. Acta
Chemically defined medium for rat astroglial cells in primary culture
Int. J. Dev. Neurosci.
A platelet factor stimulating human normal glial cells
Exp. Cell Res.
Stimulation of oligodendroglial proliferation and maturation by interleukin 2
Nature (London)
Cited by (85)
Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro
2012, Neurochemistry InternationalCitation Excerpt :Moreover, axotomy (Barres and Raff, 1993), or action potential blockade (Demerens et al., 1996), decreases OL progenitor (OLP) number, and inhibits myelination in vitro, respectively. Molecules that could account for these interactions (review in Bozzali and Wrabetz, 2004) include adenosine (Stevens et al., 2002), or platelet-derived growth factor, which is released by neurons and stimulates OLP proliferation (e.g. Besnard et al., 1987; Richardson et al., 1988), or remyelination (Allamargot et al., 2001). Neuronal neuregulins also increase OLP growth and maturation (Brinkmann et al., 2008; Taveggia et al., 2008), and adhesion molecules intervene (Falk et al., 2002; Coman et al., 2005).
In vivo targeting of subventricular zone astrocytes
2010, Progress in NeurobiologyDicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
2010, NeuronCitation Excerpt :We looked for predicted miR-219 targets that were repressed >2-fold in OLs relative to OPCs that were also either (1) computationally determined to be very likely targets of miR-219 (Table S2), (2) very highly repressed during OL differentiation (Table S3), or (3) very highly expressed in OPCs (Table S4). From these analyses, we selected four candidate genes for further study: PDGFRα, the receptor for the OPC mitogen PDGF (Besnard et al., 1987), Sox6, a transcription factor previously reported to repress terminal OL differentiation (Stolt et al., 2006), and also FoxJ3 and ZFP238 (a.k.a. RP58), two transcription factors with no previously reported functions in OPCs. ZFP238 is a transcriptional repressor expressed in neuronal precursors and distinct subsets of mature neurons that has been implicated in regulating neuronal differentiation (Aoki et al., 1998; Okado et al., 2009), and FoxJ3 expression has been detected in various developing tissues, including the embryonic neural tube (Landgren and Carlsson, 2004).
Regulation of cell cycle progression in astrocytes
2003, Advances in Molecular and Cell BiologyA single intracerebral microinjection of platelet-derived growth factor (PDGF) accelerates the rate of remyelination in vivo
2001, Brain ResearchCitation Excerpt :Glial tumoural transformation was never observed in the central nervous system (not shown). PDGF is a potent mitogen for post-natal [9,43,49,50], as well as for adult O-2A progenitors [20,55] in vitro. Moreover, ex vivo gene delivery of PDGF to adult rats increased the number of O-2A progenitors in the spinal cord [31].