Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain
References (22)
- et al.
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease
Neurosci. Lett.
(1986) - et al.
Motor effects of serotonin in the central nervous system
Life Sci.
(1980) - et al.
Morphometric studies of the neuropathological changes in choreatic diseases
J. Neurol. Sci.
(1976) - et al.
Determination of gamma-aminobutyric and glutamic acids in rat brain by liquid chromatography with electrochemical detection
Life Sci.
(1984) - et al.
The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain
Brain Res.
(1984) - et al.
The influence of agonal status on some neurochemical activities of postmortem human brain tissue
Neurosci. Lett.
(1982) Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction
Neurosci. Lett.
(1982)- et al.
Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects
J. Neurol. Sci.
(1980) - et al.
Verteilung des 5-Hydroxytryptamins (Serotonin) im Gehirn des menschen und sein Verhalten bei Patienten mit Parkinson Syndrom
Klin. Wochenschr.
(1961) - et al.
Brain amines in Huntington's Chorea
Huntington's chorea - post-mortem measurement of glutamic acid decarboxylase, choline acetyl-transferase and dopamine in basal ganglia
Brain
Cited by (69)
Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea
2011, Parkinsonism and Related DisordersCitation Excerpt :Such striatal atrophy would inevitably result in an increase in the density of 5-HT axon varicosities, unless a significant loss of such terminals occurs. Striatal atrophy could also explain the above-normal level of striatal 5-HT noted in post-mortem biochemical studies of HD [15,30]. In the HD cases we examined, 5-HT innervation was increased in the putamen and the caudate nucleus but relatively unaltered in the nucleus accumbens.
Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism
2010, Free Radical Biology and MedicineHuntington's disease: Pathogenesis to animal models
2010, Pharmacological ReportsCitation Excerpt :Disruptions in GABA systems are not limited to the striatum. Reynolds and Pearson [94] have shown decreased GABA levels in the hippocampus and cerebral cortex as well as reduced levels of the synaptic enzyme GAD throughout the brain. Different neuronal circuits expressing various pathways are shown in Figure 3.
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
2008, Neurobiology of DiseaseCitation Excerpt :These reports are in contrast to those reported in human postmortem HD brains, however. Specifically, several groups have found that 5-HT levels are elevated in blood and brains of HD patients (Reynolds and Pearson 1987; Kish et al., 1987; Beal et al., 1990). One possibility is that striatal atrophy that occurs in HD may account for these findings.