Elsevier

Neuroscience Letters

Volume 97, Issues 1–2, 13 February 1989, Pages 97-102
Neuroscience Letters

Multiple voltage-sensitive K+ channels regulate dendritic excitability in cerebellar Purkinje neurons

https://doi.org/10.1016/0304-3940(89)90146-8Get rights and content

Abstract

Ionic conductances present in the dendritic region of the cerebellar Purkinje neuron were studied using the single-channel and whole-cell recording methods. Several types of voltage-sensitive K+ channels including a Ca2+ activated K+ channel were found to be a prominent components of the dendritic membrane. All patches studied contained K+ channel types and most patches contained more than one K+ channel type. In cell attached recordings, K+ channel activity was associated with the late phase of spontaneous action potentials suggesting a functional relationship. These data demonstrate that voltage-sensitive ion channels contribute to dendritic excitability and suggest that the transduction and integration of synaptic signals may involve both active and passive ionic conductances.

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