Elsevier

Neuroscience Letters

Volume 113, Issue 2, 31 May 1990, Pages 144-150
Neuroscience Letters

MK801 induces c-fos protein in thalamic and neocortical neurons of rat brain

https://doi.org/10.1016/0304-3940(90)90294-JGet rights and content

Abstract

MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5–8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK801 is unclear, however the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.

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    First, microdialysis studies in freely moving rats have indicated that systematic MK801 administration (0.2–0.5 mg/kg) significantly increases extracellular DA levels in the prefrontal cortex and the NAc but not in the CPu (Mathe et al., 1996; Wedzony et al., 1993; Wolf et al., 1993). In addition, previous studies indicated that moderate to high doses of MK801 (0.5–8.0 mg/kg) may induce Fos-like protein expression in various brain regions including the striatum (Dragunow and Faull, 1990; Liu et al., 1994; Storvik et al., 2006). However, in both CPu and NAc, low dose of MK801 (0.1–0.3 mg/kg) itself had no effect on c-fos mRNA induction (De Leonibus et al., 2002; Dalia and Wallace, 1995).

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