The mucosal potential elicited by noxious chemical stimuli with CO2 in rats: Is it a peripheral nociceptive event?

doi:10.1016/0304-3940(91)90283-Y

Neuroscience Letters

Volume 128, Issue 2, 22 July 1991, Pages 297-300

https://doi.org/10.1016/0304-3940(91)90283-Y Get rights and content

Abstract

Negative mucosal potentials (NMPs) were recorded from the nasal respiratory mucosa in rats following retrograde stimulation with CO₂ through a tube advanced to the nasopharynx. Local application of capsaicin (3 mg in 0.3 ml solvent, n = 5) and lidocaine (31 mg in 0.3 ml solvent, n = 5) eliminated the NMPs and cortical responses in the EEG. A quantitative reduction in NMPs was found following systemic pretreatment with capsaicin (cumulative dose, 200 mg/kg, n = 4), but not with guanethidine (50 mg/kg s.c., n = 4). Blood flow measurements and NMPs were obtained from the same recording position (n = 4). Onset of blood flow changes (1200–4800 ms) appeared significantly later than the onset of NMPs (120–500 ms). On the basis of these results a sensory neurogenic origin of the NMP is assumed.

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The mucosal potential elicited by noxious chemical stimuli with CO2 in rats: Is it a peripheral nociceptive event?

Abstract

Pain

Brain Res.

Neuroscience

Neurosci. Lett.

The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species

Br. J. Pharmacol.

The mucosal potential elicited by noxious chemical stimuli with CO₂ in rats: Is it a peripheral nociceptive event?