Elsevier

Neuroscience Letters

Volume 158, Issue 2, 20 August 1993, Pages 167-169
Neuroscience Letters

NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide

https://doi.org/10.1016/0304-3940(93)90255-JGet rights and content

Abstract

Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, l-arginine did not augment and l-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.

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Current address: Department of Anatomy, University of Toronto, Toronto, Ont., Canada M5S 1A8.

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