Vesicle monoamine transporters 1 and 2: differential distribution and regulation of their mRNAs in chromaffin and ganglion cells of rat adrenal medulla
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The recent progress in animal models of depression
2017, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :The vesicular monoamine transporter (Vmat) is comprised of two proteins: Vmat1 and Vmat2. Vmat1 is enriched in the chromaffin, whereas Vmat2 is mainly expressed in monoaminergic neurons (Mahata et al., 1993). The growth of homozygous Vmat2 −/− mice show major retardation and these mice die within a few days after birth.
The Chromogranin A-derived sympathomimetic serpinin depresses myocardial performance in teleost and amphibian hearts
2017, General and Comparative EndocrinologyCitation Excerpt :It is present in teleost fish (Deftos et al., 1987), amphibians (Reinecke et al., 1991), reptiles (Trandaburu et al., 1999), birds (Reinecke et al., 1991), humans, pigs and rats (Tota et al., 2007; Helle et al., 2007). CgA-positive cells have been detected in a number of mammalian species during early developmental stages in the adrenal medulla and the gastro-entero-pancreatic system together with various endocrine cells (Kent and Coupland, 1989; Mahata et al., 1993; Wang et al., 1994; Kameda et al., 1998). CgA-positive cells are also present in the brain and the dorsal root ganglia of the zebrafish (Danio rerio) (Xie et al., 2008), suggesting a role during the early embryonic stages.
Vesicular monoamine transporter 2 (Vmat2) knockdown elicits anxiety-like behavior in zebrafish
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :And there are two subtypes: Vmat1 and Vmat2. Vmat1 is highly expressed in the peripheral tissues, whereas Vmat2 is dominant in the central neural system [4]. Vmat2 has been found to be involved in monoamine storage and quantal secretion of neurotransmitters, and thus VMAT2 dysfunction results in neurological and psychiatric disorders.
Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion
2012, NeuropharmacologyCitation Excerpt :The vesicular monoamine transporter (Vmat) exists in two isoforms. Vmat1 is expressed in the chromaffin and enterochromaffin cells, while Vmat2 is the main isoform expressed in monoaminergic neurons (Mahata et al., 1993). Vmat2 −/− newborn mice have major depletion of all monoamines and die within a few days after birth (Alvarez et al., 2002; Fon et al., 1997; Wang et al., 1997).
Pheochromocytoma
2008, Medicine