Linkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice

Abstract

The implication of the sex-specific part of the Y-chromosome (Y^S-SP) on brain serotonin (5-HT) level was investigated using congenic strains for this chromosomal region. The 5-HT level, which was higher in the NZB than in the CBA/H strain of mice, was depleted by the transfer of the Y^S-SP from NZB on CBA/H whereas the transfer of the Y^S-SP from CBA/H on NZB had no effect. The variations of 5-HT levels were not correlated with plasma testosterone concentration which is also dependent of the Y^S-SP.