Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor
References (28)
- et al.
The effects of repetitive low frequency stimulation on control and ‘potentiated’ synaptic responses in the hippocampus
Life Sci.
(1980) - et al.
Possible involvement of nitric oxide in long-term potentiation
Eur. J. Pharmacol.
(1991) - et al.
Nitric oxide synthase: irreversible inhibition by in brain in vitro and in vivo
Biochem. Biophys. Res. Commun.
(1991) - et al.
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway
Neurosci. Lett.
(1991) - et al.
Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices
Brain Res.
(1991) - et al.
Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices
Neurosci. Lett.
(1993) - et al.
The role of nitric oxide in hippocampal long-term potentiation
Neuron
(1992) - et al.
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
Neuron
(1992) - et al.
Nitric oxide-induced blockade of NMDA receptors
Neuron
(1992) A simplification of the protein assay method of Lowry et al. which is more generally applicable
Anal. Biochem.
(1977)
Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation
Brain Res.
The suppression of long-term potentiation in rat hippocampus by inhibitors of nitric oxide synthase is temperature and age dependent
Neuron
A role for nitric oxide in long-term potentiation
Eur. J. Neurosci.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
Cited by (77)
Nitrinergic Signalling in Object Novelty Recognition
2018, Handbook of Behavioral NeuroscienceCitation Excerpt :Despite the strong evidence implicating NO signalling in LTP induction, contradictory findings challenge the above idea. A few studies showed no effect of NOS inhibitors on hippocampal or cerebellar plasticity by means of LTP and LTD, respectively (O'dell et al., 1991; Bannerman et al., 1994; Boulton et al., 1994; Cummings et al., 1994). The contradictory findings could be explained by experimental differences and manipulations, including concentration of the inhibitors, time of application, induction protocol and stimulating area.
NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Other studies indicate that tyrosine phosphatases such as STEP (striatal enriched phosphatase) may also participate in metaplasticity (Pelkey et al., 2002; Yang et al., 2006). Additionally, some (Izumi and Zorumski, 1993; Reyes-Harde et al., 1999) but not all (Cummings et al., 1994) studies indicate that NO plays a role in LTD, adding to possible interactions between metaplasticity and LTD. Release of adenosine may also contribute to both LTD and LTP inhibition (Fujii et al., 2000).
Nitric oxide neurons and neurotransmission
2010, Progress in NeurobiologyNitric oxide signaling pathways at neural level in invertebrates: Functional implications in cnidarians
2008, Brain ResearchCitation Excerpt :NO has been identified in the mammalian brain in which it plays a role as neurotransmitter and neuromodulator (Vincent, 1994; Garthwaite and Boulton, 1995). Although NO is not regarded as a classical neurotransmitter, several studies in the mammalian central nervous system have suggested a critical role for NO in the hippocampus of long-term potentiation (LTP) and long-term depression (LTD) (Haley et al., 1992; Cummings et al., 1994). A role of NO as neurotransmitter has also been established in mammalian peripheral nerves at non-adrenergic/non-cholinergic synapses (Rand and Li, 1995).
A critical survey on nitric oxide synthase expression and nitric oxide function in the retinotectal system
2007, Brain Research ReviewsCitation Excerpt :Although many reports have shown a role of NO in synaptic plasticity and in memory and learning, it is also important to comment that this role was not confirmed by other experiments. Many reports have described no impairment in hippocampal LTP (Williams et al., 1993; Boulton et al., 1994; Cummings et al., 1994; Murphy et al., 1994), in cerebellar LTD (Glaum et al., 1992; Linden and Connor, 1992; Hemart et al., 1995), and in learning (Bannerman et al., 1994; Mogensen et al., 1995; Wortwein et al., 1997; Blokland et al., 1999) after NOS inhibition. The involvement of NO in synaptic plasticity and learning is generally accepted, but the inconsistency in the reported results reveals that this role is still under discussion.