Elsevier

Neuroscience Letters

Volume 185, Issue 3, 13 February 1995, Pages 163-166
Neuroscience Letters

Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication

https://doi.org/10.1016/0304-3940(95)11251-QGet rights and content

Abstract

Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are cytokines released by activated immune cells. IL-1β and TNF-α elicit various illness symptoms including avoidance of novel tastes with which they have been paired (conditioned taste aversion). Previous hypotheses to account for these actions have focused on blood-borne IL-1β and TNF-α exerting their effects directly at the brain. However, recent evidence suggests that these cytokines may active subdiaphragmatic vagal afferents. The present experiments demonstrate that subdiaphragmatic vagal transection both attenuates acquisition and facilitates extinction of conditioned taste aversions induced by i.p. administration of either IL-1β or TNF-α.

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