The clinically tested N-methyl-d-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy
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2021, Treatments, Mechanisms, and Adverse Reactions of Anesthetics and AnalgesicsThe transition from naïve to primed nociceptive state: A novel wind-up protocol in mice
2016, Experimental NeurologyCitation Excerpt :Furthermore, the results show for the first time, that blocking NMDA receptors prior to WU stimulation prevented the development of mechanical allodynia, but not the hypersensitivity to heat. Other studies have shown differential effects of NMDA blockers on mechanical allodynia vs. thermal hypersensitivity; in some models they blocked enhanced sensitivity to heat (Chen and Chen, 2000; Davar et al., 1991; Dickenson and Sullivan, 1987; Eisenberg et al., 1995; Wegert et al., 1997), in others they blocked enhanced sensitivity to mechanical (touch) stimulation (Carlton and Hargett, 1995; Lee et al., 2002; Ma and Woolf, 1995; Sandkuhler, 2009; Smith et al., 1994; Wegert et al., 1997). It is known that NMDA receptors are critical in producing and maintaining central sensitization (Woolf and Thompson, 1991; You et al., 2003b).
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