Vasoactive intestinal peptide regulates extracellular adenosine levels in rat cortical cultures☆
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Cited by (21)
Role of PACAP and VIP in astroglial functions
2007, PeptidesTonic adenosine A<inf>1</inf> and A<inf>2A</inf> receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus
2007, NeuropharmacologyCitation Excerpt :By themselves, CPA (15 nM) reduced the fEPSP slope by 49.9 ± 3.7% (n = 4) and CGS21680 (10 nM) enhanced the fEPSP slope by 10.0 ± 2.0% (n = 4). The ability of A1 and A2A receptor agonists to rescue the facilitatory effect of VIP in the presence of ADA precludes the remote possibility that VIP was facilitating synaptic transmission by enhancing the release of endogenous adenosine, as it has been proposed for the VIP enhancement of cAMP production in hippocampal slices (Rosenberg and Li, 1995). ZM241385 can inhibit A1 receptor-mediated actions in the hippocampus (Lopes et al., 1999).
Zaprinast stimulates extracellular adenosine accumulation in rat pontine slices
2004, Neuroscience Letters
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P.A.R. is supported by PHS grants (NS26830 and NS31353), an Established Investigatorship from the American Heart Association, and a Mental Retardation Core Grant to Children's Hospital.
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We wish to thank Sara Vasquez for excellent technical assistance in producing and maintaining cortical cultures.