Elsevier

Neuroscience Letters

Volume 202, Issue 3, 5 January 1996, Pages 161-164
Neuroscience Letters

Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth

https://doi.org/10.1016/0304-3940(95)12235-4Get rights and content

Abstract

A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.

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A portion of this work is published in abstract form. Supported by NIA 44626, NS54982, MH45530.

1

Current address: Department of Biology, Yonsei University School of Natural Sciences, Seoul, South Korea.

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