Memantine reduces functional and morphological consequences induced by global ischemia in rats
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Cited by (60)
Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice
2018, Journal of Stroke and Cerebrovascular DiseasesThe Effects of Memantine on Glutamic Receptor–Associated Nitrosative Stress in a Traumatic Brain Injury Rat Model
2018, World NeurosurgeryCitation Excerpt :Memantine (3,5-dimethyl-1-adamantanamine), a blood-brain barrier–permeable and selective NR2B antagonist, has been used clinically for the treatment of dementia and Parkinson disease for years. It also has neuroprotective effects in different neural injury models such as ischemia and hemorrhage.11-15 According to Walker,16 TBI and Alzheimer disease have similar pathophysiologic pathways, one of which is caused by increased concentrations of glutamate.
Effects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion model
2015, Neurology Psychiatry and Brain ResearchCitation Excerpt :In addition, it contributes to the initiation of events leading to apoptosis.17,18 Because NMDA receptor antagonists have been available for several years, many studies have emphasized the role of NMDA receptors in ischemic cell loss.10,19 Some studies reported that memantine had positive effects on experimental cerebral ischemia in rats, as the mean infarct size and apoptosis of rats treated with memantine were significantly lower than those of the control group.
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Present address: Department of Neurology, Pauwelsstrasse 30, D52057 Aachen, Germany.