Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness☆
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Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease
2014, Neurobiology of DiseaseCitation Excerpt :Virtually nothing is known about the mechanisms underlying the beneficial effects of bright light, while a number of studies have shown that non-photic entrainment via voluntary or forced exercise involves the midbrain serotonergic raphe nuclei (Morin and Allen, 2006; Webb et al., 2010) that is known to innervate the SCN (Meyer-Bernstein and Morin, 1996). The serotonergic system is implicated in the regulation of the circadian rhythms in both diurnal and nocturnal species (Cuesta et al., 2008; Cutrera et al., 1996) and activity of serotonergic neurons is closely correlated with the behavioral arousal level (Jacobs and Fornal, 1999). Thus serotonin represents a good candidate in the mediation of the effects observed in the present study.
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice
2012, NeuropharmacologyCitation Excerpt :In our hands (Experiment 4), LP-211 seems to induce a phase advancement on spontaneous circadian rhythm in mice which do not have daily temporal landmarks. In more detail, the 0.25 mg/kg dosage of LP-211 produced a phase advancement of about 6 h (that is, more than what was reported with 8–OH–DPAT in similar experimental conditions, see Cutrera et al., 1996). We propose that, compared to LP-211 which is a pure and selective agonist, 8–OH–DPAT could be characterized by a lower 5-HT(7) agonist property, thus explaining its reduced efficacy.
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This research was supported by a grant from the Commission of the European Communities, Brussels (EC contract CT-94-0036).
- 1
Present address: Laboratorio de Neurociencias, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
- 2
During the present work, R.A. Cutrera was a postdoctoral fellow from EC (EC Contract C11 0636-M) and now is a permanent researcher from CONICET (National Research Council of Argentina).