Low pH facilitates capsaicin responses in isolated sensory neurons of the rat☆
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Cited by (44)
Molecular Mechanisms of TRPV1-Mediated Pain
2009, NeuroImmune BiologyCitation Excerpt :For example, a dish made with chili pepper produces a more intense burning sensation when it is warm than when it is cold. It seems that this “cooperation” of various ligands is synergistic, rather than additive, in activating TRPV1 [24,46,108]. The findings that various ligands potentiate each other’s effect on TRPV1 indicate that the different activator sites are coupled in TRPV1.
Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs
2007, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Other inflammatory mediators such as prostaglandin E2, which are known to increase capsaicin-induced TRPV1 current in pulmonary sensory neurons from rats may also be released in SO2 exposure-induced inflammatory airways and contribute to increased TRPV1 activity [42]. In addition, acidification is known to increase the TRPV1 channel activity in response to capsaicin and heat [43–45]. Decreased pH was detected in some inflammatory airway diseases [46].
Role of TRPV receptors in respiratory diseases
2007, Biochimica et Biophysica Acta - Molecular Basis of DiseaseVanilloid receptor 1 (VR1): an integrator of noxious and inflammatory stimuli<sup>*</sup>
2004, Advances in Molecular and Cell BiologyCitation Excerpt :The slope factors estimated from pH–response curves are close to 2 for both cloned [13,14] and native [79] channels, which suggests that the binding of 2 protons is needed to activate VR1. In addition to their ability to directly gate channels, low pH solutions also facilitate the response of DRG neurons to capsaicin [82–84] such that low concentrations of capsaicin can have a large agonist effect (Fig. 4B). The augmentation results from an increase in the probability of channel opening at these capsaicin concentrations with little or no change in single channel conductance [84,85].
Anandamide Activates Vanilloid Receptor 1 (VR1) at Acidic pH in Dorsal Root Ganglia Neurons and Cells Ectopically Expressing VR1
2001, Journal of Biological ChemistryCitation Excerpt :The combined effect of high eicosanoid release and low pH might contribute to pain signaling to the CNSin vivo. Previously, acidification was noted to sensitize nociceptive neurons toward vanilloids (40, 41) and eicosanoids including, but probably not confined to, PGE2 and prostacyclin (18, 20, 21, 42, 43). In addition to acid-sensitive sodium ion channels (44-46), recent point mutation studies implicate H+ as a direct regulator of VR1.
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This work was supported by the European Union (CIPA-CT93-0026) and by the DFG (SFB 353, B12).
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The authors thank Ms. Annette Kuhn and Ms. Iwona Izydorczyk for excellent technical assistance.