Elsevier

Neuroscience Letters

Volume 211, Issue 1, 14 June 1996, Pages 57-60
Neuroscience Letters

Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat

https://doi.org/10.1016/0304-3940(96)12720-8Get rights and content

Abstract

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk B mRNA, in brain. In situ hybridization studies showed that BDNF and trk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemic MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct which could survive.

References (26)

  • A. Tamura et al.

    Atrophy of the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat

    Brain Res.

    (1990)
  • M.C. Comelli et al.

    Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression

    NeuroReport

    (1992)
  • P. Ernfors et al.

    Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain

  • Cited by (0)

    View full text