General Pharmacology: The Vascular System
ReviewAdenosine transporters☆
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Cited by (205)
Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
2019, EBioMedicineCitation Excerpt :Adenosine can be generated from the dephosphorylation of extracellular ATP by CD39 and CD73, by intracellular s-adenosyl-homocysteine hydrolysis, and through de novo purine biosynthesis [12]. Since adenosine is a hydrophilic polar molecule that is incapable of penetrating the cell membrane via passive distribution, the equilibrative nucleoside transporters (ENT) and concentrative nucleoside transporters (CNT) maintain a dynamic exchange between the extracellular and intracellular sources of adenosine [13,14]. As a vital component of purinergic signalling, adenosine along with its metabolites, inosine and cAMP, can participate directly in the regulation of metabolism homeostasis and DNA replication.
Spherical-supported membranes as platforms for screening against membrane protein targets
2018, Analytical BiochemistrySugar-modified poly(propylene imine) dendrimers as drug delivery agents for cytarabine to overcome drug resistance
2016, International Journal of Pharmaceutics
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Work in this laboratory during the past 5 years, part of which has been summarized in this review, was supported by grants from the Medical Research Council, the National Kidney Research Fund, the Nuffield Foundation, the British Council and the Royal Society.