Calcium-dependent release of d-[3H]aspartate evoked by selective electrical stimulation of excitatory afferent fibres to hippocampal pyramidal cells in vitro
References (48)
- et al.
Long-term and short-term plasticity in the CA1, CA3, and dentate regions of the rat hippocampal slice
Brain Res.
(1976) - et al.
Functional characteristics of unmyelinated fibres in the hippocampal cortex
Brain Res.
(1978) - et al.
Specific release of endogenous glutamate from piriform cortex stimulated in vitro
Brain Res.
(1976) - et al.
Hippocampal inputs to the lateral septal nucleus: patterns of facilitation and inhibition
Brain Res.
(1972) In vitro excitation of hippocampal pyramidal cell dendrites by glutamic acid
Neuropharmacology
(1974)- et al.
Effect of frontal cortex ablation on striatal glutamic acid level in rat
Brain Res.
(1977) - et al.
Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats
Brain Res.
(1978) - et al.
A glutamatergic corticostriatal pat
Brain Res.
(1977) - et al.
Inhibition of the high-affinity, net uptake of GABA into cultured astrocytes by β-proline, nipecotic acid and other compounds
Brain Res.
(1978) Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation
Brain Res.
(1975)
Cellular and field potential properties of epileptogenic hippocampal slices
Brain Res.
Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice
Brain Res.
The transverse hippocampal slice: a well-defined cortical structure maintained in vitro
Brain Res.
Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy
Brain Res.
Uptake of [3H]glutamic acid in excitatory nerve endings. Light and electronmicroscopic observations in the hippocampal formation of the rat
Neuroscience
Aspartate and/or glutamate may be transmitters in hippocampal efferents to septum and hypothalamus
Neuroscience Letters
The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat
Neuroscience
Organization of hippocampal neurons and their interconnections
Long-lasting facilitation of synaptic transmission
Organization of the hippocampal output
Expl Brain Res.
Unit analysis of hippocampal population spikes
Expl Brain Res.
Lamellar organization of hippocampal excitatory pathways
Expl Brain Res.
The structural specificity of the high affinity uptake ofl-glutamate andl-aspartate by rat brain slices
J. Neurochem.
Glutamate as a CNS neurotransmitter: properties of release, inactivation and biosynthesis
Cited by (70)
New insights on the influence of free D-aspartate metabolism in the mammalian brain during prenatal and postnatal life
2020, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :Moreover, microdialysis experiments carried out in the PFC of freely moving mice revealed that d-Asp is present at nanomolar concentrations in the extracellular space and its release occurs via Ca2+-dependent mechanisms [20,50]. In support of these in vivo results, previous in vitro findings showed that d-Asp can be stored in secretory granules [51], released through vesicular Ca2+-mediated exocytosis [22,51–53] and taken up at both nerve terminals and glia via Na+/K+ electrochemical L-Glu/L-Asp transporter system [54–56]. Besides a direct effect of d-Asp on the activation of postsynaptic NMDAR and mGluR5, recent research showed that exogenous administration of this d-amino acid evokes a considerable extracellular release of L-glutamate in the PFC of freely moving mice through the stimulation of presynaptic NMDA, AMPA and mGlu5 receptors [50].
D-Aspartate: An endogenous NMDA receptor agonist enriched in the developing brain with potential involvement in schizophrenia
2015, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :If this is the case, it is conceivable to hypothesize mechanisms accounting for the hypothetical release and subsequent removal of this d-amino acid from synapses. Different works using mammalian tissue slices, cells or synaptosomal preparations have suggested that d-Asp can be released through vesicular Ca2+-mediated exocytotic processes [31,47,64–66] which would presume that secretory organelles in subset of cells are able to actively store d-Asp [66]. Accumulation of [3H]d-Asp, together with [3H]l-Glu and [3H]l-Asp, has been demonstrated in synaptosomal vesicular pool of rat brain [67].
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility
2008, Molecular and Cellular Neuroscienced-Aspartic acid: An endogenous amino acid with an important neuroendocrine role
2007, Brain Research ReviewsCitation Excerpt :This carrier protein, which transports l-Glu from the glial cells to the terminal axons, is also efficiently capable of transporting d-Asp from the synaptic clefts to the neurons (Bouvier et al., 1992). Endogenous d-Asp or accumulated [3H]d-Asp is released from the rat cerebellum slices or from cultured astrocytes by depolarizing stimuli induced by potassium ions via a calcium channel-dependent mechanism, just as it occurs for other neurotransmitters (Davies and Johnton, 1976; Hopainen et al., 1990; Levi et al., 1982; Malthe-Sorenssen et al., 1979). The same events occur in the guinea pig spinal cord (Potashner et al., 1988).
Characterization of electrically evoked [<sup>3</sup>H]-D-aspartate release from hippocampal slices
2001, Neurochemistry International