1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian syndrome in Macaca fascicularis: Which midbrain dopaminergic neurons are lost?
References (47)
- et al.
Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Life Sci.
(1986) - et al.
Current concepts: III. Primate model of parkinsonism: selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys
Life Sci.
(1985) - et al.
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
Psychiat. Res.
(1979) - et al.
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Neurosci. Lett.
(1986) - et al.
Monoamine distribution in primate brain.V. Monoaminergic nuclei
Brain Res. Bull.
(1983) - et al.
Localization of nigrostriatal, nigrothalamic and nigrotectal neurons in ventricular coordinates in macaques
Neuroscience
(1984) - et al.
Morphological and functional aspects of central monoamine neurons
Int. Rev. Neurobiol.
(1970) - et al.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset
Neurosci. Lett.
(1984) - et al.
Protein measurement with folin phenol reagent
J. biol. Chem.
(1951) - et al.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is toxic to mesencephalic DA neurons in culture
Neurosci. Lett.
(1985)
Effects of n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its metabolite, n-methyl-4-phenylpyridinium ion, on dopaminergic nigrostriatal neurons in the mouse
Neurosci. Lett.
Specificity of antisera prepared against pure bovine MAO-B
Brain Res.
Comparative morphology of the substantia nigra and ventral tegmental area in the monkey, cat and rat
Brain Res. Bull.
Histochemical mapping of catecholaminergic neurons and their ascending fiber pathways in the rhesus monkey brain
Brain Res. Bull.
Estimation of nuclear population from microtome sections
Anal. Rec.
Midbrain dopamine neurons in man: effects of Parkinson's disease on the regional distribution of cells
Neurosci. Abstr.
A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics
Biol. Psychiat.
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man
Can. J. Neurol.
Jacket and swivel tethering systems
Lab. Anim.
Selective neurotoxic effects of n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in subhuman primates and man: A new animal model of Parkinson's disease
Psychopharmacol. Bull.
Evidence for the existence of monoamine-containing neurons in the central nervous system
Acta physiol. scand.
Cited by (199)
The neurobiological effects of senescence on dopaminergic system: A comprehensive review
2024, Journal of Chemical NeuroanatomyAcrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration
2019, Molecular and Cellular NeuroscienceDirect intranigral injection of dopaminochrome causes degeneration of dopamine neurons
2016, Neuroscience LettersTyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism
2014, Journal of the Neurological SciencesDifferential effects of intrastriatal 6-hydroxydopamine on cell number and morphology in midbrain dopaminergic subregions of the rat
2014, Brain ResearchCitation Excerpt :However, most post-mortem studies of PD have examined an advanced stage of neuronal loss in which SNpc neurons are decreased by 70% or more (Hirsch et al., 1988). In PD, neuronal loss from the VTA, which projects chiefly to limbic and cortical brain regions (Oades and Halliday, 1987; van Domburg and ten Donkelaar, 1991), is similar to that in the RRF, but less than in the SNpc (German et al., 1988, 1996; Hirsch et al., 1988; Hirsch, 1994; Rodríguez et al., 2001; Uhl et al., 1985). Interestingly, in PD as well as in animal models of the disease with extensive dopaminergic cell loss, the ultimate level of neuronal loss in the VTA and RRF peaks at around 70% for the RRF neurons, and at around 60% for the VTA neurons in most studies (German et al., 1988, 1996; Hirsch et al., 1988; Rodríguez et al., 2001; Uhl et al., 1985).
Value Learning through Reinforcement: The Basics of Dopamine and Reinforcement Learning
2013, Neuroeconomics: Decision Making and the Brain: Second Edition