Synaptic organization of intracellularly stained CA3 pyramidal neurons in slice cultures of rat hippocampus
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Cited by (94)
Energy deprivation transiently enhances rhythmic inhibitory events in the CA3 hippocampal network in vitro
2010, NeuroscienceCitation Excerpt :Paired Student's t-tests were used to compare responses under the various conditions. All experiments were performed with roller-drum hippocampal slice cultures where synaptic connectivity approaches that found in vivo (Zimmer and Gähwiler, 1984; Frotscher and Gähwiler, 1988). Thus, broad band oscillatory activity is much more readily induced in this preparation (Fischer et al., 2002) than in acute hippocampal slices in which rhythmicity is usually restricted to a single band and requires application of very high concentrations of agonists (Konopacki et al., 1987; MacVicar and Tse, 1989; Williams and Kauer, 1997; Fisahn et al., 1998; Gillies et al., 2002).
CA3 axonal sprouting in kainate-induced chronic epilepsy
2005, Brain ResearchCitation Excerpt :This sprouting response particularly to widespread levels of the lateral entorhinal cortex may also suggest a means to explain the latency in generation of spontaneous recurrent seizures following an initial excitotoxic insult. Frotscher and Gahwiler using a slice preparation intracellularly labeled CA3 neurons and evaluated dendritic and axonal arborization [15]. They reported that the vast majority of Schaffer collaterals traveled towards the CA1 subfield and smaller numbers towards the hilus.
Repeated stress and structural plasticity in the brain
2005, Ageing Research ReviewsMaturation of cultured hippocampal slices results in increased excitability in granule cells
2005, International Journal of Developmental NeuroscienceCitation Excerpt :Although the resting membrane potential did not differ between the cultured and acutely prepared slices, the total denervation of dentate granule cells during the slice preparation could lead to reorganization of the hippocampal circuitry in cultured slices (Caeser and Aertsen, 1991, Frotscher et al., 1995) and, at least partly, explains the differences in the excitability between the cultured and acutely prepared hippocampal tissue. It has earlier been shown that the growth and reorganization of MFs occur in cultured slices (Frotscher and Gähwiler, 1988; Coltman et al., 1995) in keeping with our present findings with biocytin staining, and with earlier intracellular recordings in cultured slices (Gutierrez and Heinemann, 1999). This is preceded by a progressive increase in the excitatory drive to the dentate granule cells.
Synaptic reorganization in explanted cultures of rat hippocampus
1999, Brain Research